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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Anti-complementary activity of a degraded sulfated heterogalactan from red alga Pyropia haitanensis
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Anti-complementary activity of a degraded sulfated heterogalactan from red alga Pyropia haitanensis

机译：来自红藻毒素的硫酸吡喃酸的抗互补活性Haitanensis

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摘要

A sulfated galactan LP-G2 was isolated and purified from red alga, Pyropia hailanensis. It was a branched polysaccharide with average molecular weight about 8381 Da, composed of Gal, Glc, GalA and Ara. The structure of LP-G2 was determined using IR and NMR spectroscopy. It was composed of -> 4)-beta-D-galactose -> 4)-alpha-L-galactose-6-sulfate segments, with beta-D-Gk and alpha-D-galactose unit substituted at the &position of alpha-L-galactose. Functional analysis showed that LP-G2 inhibited complement activation on both the classic and alternative pathways with CH50 value of 3.08 = 025 mg/mL and AP(50) value of 223 +/- 020 mg/ml, respectively. Preliminary mechanism studies by using complement component depleted-sera indicated that LP-G2 selectively interacts with C1q, C2, C4 and C9. The results suggested that LP-G2 could be of potential benefits in treatment of the complement associated diseases. (C) 2020 Elsevier B.V. All rights reserved.
机译：分离硫酸盐的半乳糖LP-G2并从红藻，吡爹族海兰尼斯纯化。 它是一种分枝多糖，平均分子量约为8381Da，由GAL，GLC，GALA和ARA组成。 使用IR和NMR光谱法测定LP-G2的结构。 它由 - > 4）-beta-d-半乳糖 - > 4）-alpha-l-半乳糖-6-硫酸盐区段，β-d-gk和α-d-半乳糖单元取代在α- - L-半乳糖。 功能分析表明，LP-G2分别抑制了CH50值3.08 = 025mg / ml和223 +/- 020mg / ml的CH50值的经典和替代途径上的补体激活。 使用补体组分的初步机理研究耗尽血清表明LP-G2选择性地与C1Q，C2，C4和C9相互作用。 结果表明，LP-G2可能具有治疗补体相关疾病的潜在益处。 （c）2020 Elsevier B.v.保留所有权利。

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