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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Mucoadhesive properties of sulphated polysaccharides carrageenans from red seaweed families Gigartinaceae and Tichocarpaceae
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Mucoadhesive properties of sulphated polysaccharides carrageenans from red seaweed families Gigartinaceae and Tichocarpaceae

机译：红海草家族硫氨基甲基和噻吩咐硫酸多糖卡拉仑蛋白胶粘剂的粘膜性质

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摘要

The mucoadhesive properties of different types of carrageenan (kappa-, kappa/beta-, iota/kappa- and lambda-CRGs) isolated from red seaweed families Gigartinaceae and Tichocarpaceae collected on the Pacific coast were studied. We examined the interaction between CRGs and pig stomach mucin in dilute aqueous solutions using a set of methods. Measurements of the dynamic light scattering of mucin in the presence of CRG showed that the polysaccharides cause aggregation of mucin particles, as confirmed by microscopy data. The addition of CRGs to solutions of mucin resulted in the formation of a mixture that changed the charge of mucin, especially in the case of kappa- and kappa/beta-CRCs. The interaction between CRG and porcine gastric mucin in the presence of various additives confirmed that hydrogen bonds and electrostatic interactions are complemented when CRG and mucin are mixed in an aqueous medium, which is also confirmed by in vitro methods based on measurements of work of adhesion and shear stress. Kappa- and kappa/beta-CRGs that contain 3,6-anhydro-alpha-D-galactopyranose chains (DA) have high molecular weight and exhibit a high density of available hydrogen bonding groups able to interact more strongly with mucin glycoproteins. (C) 2019 Elsevier B.V. All rights reserved.
机译：研究了从红海草家族吉塔涅泰夏季夏季夏季夏季夏季夏季夏季夏季夏季夏季和Tichocarpaceae的不同类型的角叉菜胶（Kappa-，Kappa / Beta-，IOTA / Kappa和Lambda-Crgs）。我们检查了使用一组方法检查了稀水溶液中CRG和猪胃粘蛋白的相互作用。 CRG存在下粘蛋白的动态光散射的测量表明，多糖导致粘蛋白颗粒的聚集，如通过显微镜数据证实。添加CRGS至粘蛋白的溶液导致形成改变粘合蛋白的电荷的混合物，特别是在κ和κB和β-CRC的情况下。当CRG和粘蛋白在水性介质中混合时，CRG和猪胃粘蛋白之间的相互作用证实了氢键和静电相互作用，其通过基于粘附性工作的体外方法确认剪切应力。含有3,6-α-α-D-半乳糖膜（DA）的Kappa和β-Beta-Crgs具有高分子量，并且具有能够与粘蛋白糖蛋白更强烈地相互作用的可用氢键组的高密度。 （c）2019 Elsevier B.v.保留所有权利。

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