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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Cytotoxicity influence of new chitosan composite on HEPG-2, HCT-116 and MCF-7 carcinoma cells
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Cytotoxicity influence of new chitosan composite on HEPG-2, HCT-116 and MCF-7 carcinoma cells

机译:新壳聚糖复合物对HepG-2,HCT-116和MCF-7癌细胞的细胞毒性影响

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Chitosan/aroylhydrazine composite were synthesized in hydrogel form in which aroylhyrazines, heteroaroylhydrazines as well as p-tolylsulphonylhydrazine embedded in the cross linked Chitosan/oxalic acid network. Their structures were characterized by (elemental analysis, FT-IR,H-1 NMR, and XRD). Antimicrobial be-havior and Cytotoxicity screening of the examined compounds against breast, colon and hepatocellular cancer were investigated. The obtained data revealed that the examined compounds have promising cell growth inhib-itory effect on the cell lines as compared to standard. Also, some of the newly synthesized derivatives had shown better antibacterial and antifungal activities, comparing with that of the parent chitosan. (C) 2020 Elsevier B.V. All rights reserved.
机译:壳聚糖/芳酰肼复合材料以水凝胶形式合成,其中芳酰吡嗪,杂芳酰肼以及嵌入交叉连接的壳聚糖/草酸网络中的对甲苯磺酰基肼。 其结构的特征在于(元素分析,FT-IR,H-1 NMR和XRD)。 研究了抗微生物的余量和对乳腺癌,结肠和肝细胞癌的检查化合物的细胞毒性筛选。 所获得的数据显示,与标准相比,所检测的化合物对细胞系具有有前途的细胞生长抑制抑制作用。 此外,一些新合成的衍生物显示出更好的抗菌和抗真菌活性,与母壳多糖的抗菌和抗真菌活性相比。 (c)2020 Elsevier B.v.保留所有权利。

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