One-Pot Synthetic Approach toward Porphyrinatozinc and Heavy-Atom Involved Zr-NMOF and Its Application in Photodynamic Therapy

Zhou Le-Le; Guan Qun; Li Yan-An; Zhou Yang; Xin Yu-Bin; Dong Yu-Bin

首页> 外文期刊>Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics >One-Pot Synthetic Approach toward Porphyrinatozinc and Heavy-Atom Involved Zr-NMOF and Its Application in Photodynamic Therapy

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One-Pot Synthetic Approach toward Porphyrinatozinc and Heavy-Atom Involved Zr-NMOF and Its Application in Photodynamic Therapy

机译：卟啉卟啉锌和重型原子的一锅合成方法涉及Zr-NMOF及其在光动力疗法中的应用

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Herein, we report an iodine-attached Zn(II)-porphyrinic dicarboxylic building block (ZnDTPP-I-2-2H, 1) that can be introduced into UiO-66 NMOF via one-pot synthetic approach to generate a new ZnDTPP-I-2 doped UiO-66 type nano metal organic framework (NMOF) of ZnDTPP-I-2 subset of UiO-66 (2). Compared to its homologous iodine-free NMOF of ZnDTPP subset of UiO-66 (4), ZnDTPP-I-2 subset of UiO-66 (2) with heavy iodine atoms is a more effective nanosized photosensitizer for singlet oxygen generation under physiological conditions. As expected, 2 displayed a high photodynamic therapy efficacy for treatment of liver cancer cells in vitro.

机译：在此，我们报告了一种碘 - 连接的Zn（II） - 孢蛋白二羧基结构块（ZnDTPP-I-2-2H，1），其可以通过单盆合成方法引入UIO-66 NMOF，以产生新的ZnDTPP-I -2掺杂的UIO-66型纳米金属有机框架（NMOF）的UIO-66（2）的ZnDTPP-I-2子集。与其UIO-66（4）的ZnDTPP子集的同源碘NMOF相比，具有重碘原子的UIO-66（2）的ZnDTPP-I-2子集是在生理条件下的单次氧气产生更有效的纳米光敏剂。正如预期的那样，2显示出肝癌细胞在体外治疗肝癌细胞的高光动力治疗疗效。

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《Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics》 |2018年第6期|共8页
作者
Zhou Le-Le; Guan Qun; Li Yan-An; Zhou Yang; Xin Yu-Bin; Dong Yu-Bin;
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Shandong Normal Univ Collaborat Innovat Ctr Functionalized Probes Chem Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Minist Educ Jinan 250014 Shandong Peoples R China;

Shandong Normal Univ Collaborat Innovat Ctr Functionalized Probes Chem Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Minist Educ Jinan 250014 Shandong Peoples R China;

Shandong Normal Univ Collaborat Innovat Ctr Functionalized Probes Chem Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Minist Educ Jinan 250014 Shandong Peoples R China;

Shandong Normal Univ Collaborat Innovat Ctr Functionalized Probes Chem Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Minist Educ Jinan 250014 Shandong Peoples R China;

Shandong Normal Univ Collaborat Innovat Ctr Functionalized Probes Chem Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Minist Educ Jinan 250014 Shandong Peoples R China;

Shandong Normal Univ Collaborat Innovat Ctr Functionalized Probes Chem Coll Chem Chem Engn &

Mat Sci Key Lab Mol &

Nano Probes Minist Educ Jinan 250014 Shandong Peoples R China;

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中图分类化学;
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1. One-Pot Synthetic Approach toward Porphyrinatozinc and Heavy-Atom Involved Zr-NMOF and Its Application in Photodynamic Therapy [J] . Zhou Le-Le, Guan Qun, Li Yan-An, Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2018,第6期

机译：卟啉卟啉锌和重型原子的一锅合成方法涉及Zr-NMOF及其在光动力疗法中的应用
2. Protonation salt derivative with heavy-atom effect on phthalocyanine for enhanced in vitro photodynamic therapy [J] . Chen Xianglan, Li Yejing, Wang Ao, Dyes and Pigments . 2015,第Null期

机译：对酞菁具有重原子效应的质子化盐衍生物，用于增强体外光动力治疗
3. Photostable lodinated Silica/Porphyrin Hybrid Nanoparticles with Heavy-Atom Effect for Wide-Field Photodynamic/ Photothermal Therapy Using Single Light Source [J] . Koichiro Hayashi, Michihiro Nakamura, Hirokazu Miki, Advanced Functional Materials . 2014,第4期

机译：具有重原子效应的光稳定卤化二氧化硅/卟啉杂化纳米颗粒，可用于单光源的宽域光动力/光热疗法
4. Interest of a MALDI-FTICR mass spectrometry approach for identification of Protein Targets involved in Photodynamic Therapy (PDT). [C] . David da Silva, Thierry Wasselin, Benoit Maunit, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：MALDI-FTICR质谱法的兴趣鉴定光动力学治疗蛋白靶标（PDT）。
5. Synthetic porphyrinic macrocycles for photodynamic therapy and other biological applications. [D] . Bhaumik, Jayeeta. 2007

机译：合成卟啉大环化合物，用于光动力疗法和其他生物应用。
6. Organically Modified Silica Nanoparticles with Intraparticle Heavy-Atom Effect on the Encapsulated Photosensitizer for Enhanced Efficacy of Photodynamic Therapy [O] . Sehoon Kim, Tymish Y. Ohulchanskyy, Dhruba Bharali, -1

机译：在封装光敏剂有机改性二氧化硅纳米粒子与粒子内重原子效应光动力治疗的功效增强
7. Sol–Gel Process of Alkoxysilane in Emulsifier-Involved Aqueous Emulsions: A One-Pot Synthetic Route to Emulsions of Core-Shell Composite Particles and Their Applications [O] . Lin Niu, Zhengbin Xia, Liang Lei, 2012

机译：乳化剂相关水乳液中烷氧基硅烷的溶胶 - 凝胶过程：核壳复合粒子乳液的一锅合成路线及其应用

One-Pot Synthetic Approach toward Porphyrinatozinc and Heavy-Atom Involved Zr-NMOF and Its Application in Photodynamic Therapy

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