Synthesis of new pyrrolo(2,3-d)pyrimidine derivatives as antibacterial and antifungal agents.

Hilmy KM; Khalifa MM; Hawata MA; Keshk RM; el Torgman AA

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Synthesis of new pyrrolo(2,3-d)pyrimidine derivatives as antibacterial and antifungal agents.

机译：新型吡咯（2,3-D）嘧啶衍生物作为抗菌和抗真菌剂的合成。

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A series of new pyrrole derivatives, pyrrolo[2,3-d]pyrimidine derivatives, pyrrolotriazolopyrimidines and pyrrolotetrazolopyrimidines were synthesized. The evaluation of their antimicrobial activities against Staphylococcus aureus, Escherichia coli, and Candida albicans were carried out. Pyrrolo[2,3-d]pyrimidines 3a-d, 7a,e, 11d exhibited excellent activity against C. albicans with MIC 0.31-0.62 mg/mL. These compounds displayed better antifungal activity than that of standard drug (fluconazole with MIC 1.5 mg/mL). Furthermore, pyrrolo[2,3-d]pyrimidines 3b,c, 7e exhibited the best activity against S. aureus with MIC 0.31 mg/mL, compared with the standard drug (ampicillin with MIC 0.62 mg/mL). The rest of the compounds were found to be inactive against bacteria and fungi.

机译：合成了一系列新的吡咯衍生物，Pyrolo [2,3-D]嘧啶衍生物，吡咯加三唑嘧啶和吡咯二氮酰吡啶胺。进行对葡萄球菌，大肠杆菌和念珠菌和念珠菌的抗菌活性的评价。吡咯并[2,3-D]嘧啶3a-d，7a，e，11d对C.古木儿的优异活性与MIC为0.31-0.62mg / ml。这些化合物显示出比标准药物的更好的抗真菌活性（氟康唑与MIC 1.5mg / ml）。此外，与标准药物（用MIC 0.62mg / ml的氨苄青霉素0.62mg / ml）相比，Pyrrolo [2,3-D]嘧啶3b，c，c，7e表现出与mic0.31mg / ml的麦克风的最佳活性。发现其余的化合物对细菌和真菌无活性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第11期|共8页
作者
Hilmy KM; Khalifa MM; Hawata MA; Keshk RM; el Torgman AA;
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Department of Chemistry Faculty of Science Menufiya University Shebin El-Kom Egypt.;

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正文语种 eng
中图分类药学;
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专利

1. Synthesis of new pyrrolo(2,3-d)pyrimidine derivatives as antibacterial and antifungal agents. [J] . Hilmy KM, Khalifa MM, Hawata MA, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：合成新的吡咯并（2,3-d）嘧啶衍生物作为抗菌剂和抗真菌剂。
2. Synthesis of new pyrrolo(2,3-d)pyrimidine derivatives as antibacterial and antifungal agents. [J] . Hilmy KM, Khalifa MM, Hawata MA, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：新型吡咯（2,3-D）嘧啶衍生物作为抗菌和抗真菌剂的合成。
3. Synthesis of novel pyrrole and pyrrolo(2,3-d)pyrimidine derivatives bearing sulfonamide moiety for evaluation as anticancer and radiosensitizing agents. [J] . Ghorab MM, Ragab FA, Heiba HI, Bioorganic and Medicinal Chemistry Letters . 2010,第21期

机译：含磺酰胺部分的新型吡咯和吡咯醇（2,3-D）嘧啶衍生物的合成评价为抗癌和放射敏化剂。
4. Synthesis and toxicological activity of 5-nitroindazole sulfonamides derivatives as potential antimicrobial agents. Optimization of the synthesis [C] . Corina Cheptea, Andreea-Celia Benchea, Marius Găină, 2017 E-Health and Bioengineering Conference . 2017

机译：5-硝基吲唑磺酰胺衍生物作为潜在抗菌剂的合成及其毒理活性。优化合成
5. Synthesis of substituted pyrrolo[2,3-d]pyrimidines as microtubule-binding agents and HSP90 inhibitors [D] . Lin, Lu 2013

机译：取代吡咯并[2,3-d]嘧啶类化合物作为微管结合剂和HSP90抑制剂的合成
6. Annellation of Triazole and Tetrazole Systems onto Pyrrolo23-dpyrimidines: Synthesis of Tetrazolo15-c-pyrrolo32-e-pyrimidines and Triazolo15-cpyrrolo-32-epyrimidines as Potential Antibacterial Agents [O] . Chaitanya G. Dave, Rina D. Shah 2002

机译：三唑和四唑体系在吡咯并23-d嘧啶上的退火反应：替他唑并15-c-吡咯并32-e-嘧啶和三唑并15-c吡咯并 32-e嘧啶类作为潜在的抗菌剂
7. Annellation of Triazole and Tetrazole Systems onto Pyrrolo[2,3-d]pyrimidines: Synthesis of Tetrazolo[1,5-c]-pyrrolo[3,2-e]-pyrimidines and Triazolo[1,5-c]pyrrolo-[3,2-e]pyrimidines as Potential Antibacterial Agents [O] . Rina D. Shah, Chaitanya G. Dave 2002

机译：将三唑和四唑体系连接到吡咯并[2,3-d]嘧啶上：四唑并[1,5-c] - 吡咯并[3,2-e] - 嘧啶和三唑并[1,5-c]吡咯并[]的合成3,2-e]嘧啶作为潜在的抗菌剂

Synthesis of new pyrrolo(2,3-d)pyrimidine derivatives as antibacterial and antifungal agents.

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