In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model.

Raman N; Jeyamurugan R; Senthilkumar R; Rajkapoor B; Franzblau SG

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In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model.

机译：在Ehrlich腹水癌肿瘤模型中体内和对高度特异性硫醇载体载体铜（II）和锌（II）复合物的体内评价。

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A new series of copper(II) and zinc(II) complexes have been designed and synthesized using a new type of Schiff bases derived from the reaction of 3-(3-phenyl-allylidene)-pentane-2,4-dione with para substituted aniline and benzene-1,2-dithiol. Their structures have been established by analytical and spectral data. The higher varepsilon and low A( ||) values together with positive reduction potentials for these copper complexes suggest that they can mimic the functional properties of naturally occurring proteins. In vivo and in vitro antitumor functions of the complexes against Ehrlich ascites carcinoma tumor model have been investigated. The minimum inhibitory concentration of the complexes has also been investigated against Mycobacterium tuberculosis strain H37Rv. These complexes exhibit significant antitumor, cytotoxic and antituberculosis activity.

机译：设计并使用新型的Schiff碱基设计和合成了一系列新的铜（II）和锌（II）配合物，所述席位基碱源于3-（3-苯基 - 烯丙烯） - 2,4-二酮与β-2,4-二酮的反应取代的苯胺和苯-1,2-二硫醇。它们的结构已经通过分析和光谱数据建立。较高的疣隆和低A（||）值以及这些铜络合物的正降低电位表明它们可以模拟天然存在的蛋白质的功能性质。在体内和体外抗肿瘤功能对EHRLICH腹水癌肿瘤模型进行了研究。还针对结核分枝杆菌菌株H37RV研究了复合物的最小抑制浓度。这些配合物表现出显着的抗肿瘤，细胞毒性和抗尿囊活性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第11期|共14页
作者
Raman N; Jeyamurugan R; Senthilkumar R; Rajkapoor B; Franzblau SG;
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Research Department of Chemistry VHNSN College Virudhunagar-626 001 Tamil Nadu India.;

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正文语种 eng
中图分类药学;
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1. In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model. [J] . Raman N, Jeyamurugan R, Senthilkumar R, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：在艾氏腹水癌肿瘤模型上高特异性硫醇盐载体基团铜（II）和锌（II）配合物的体内和体外评估。
2. In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model. [J] . Raman N, Jeyamurugan R, Senthilkumar R, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：在Ehrlich腹水癌肿瘤模型中体内和对高度特异性硫醇载体载体铜（II）和锌（II）复合物的体内评价。
3. In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model. [J] . Raman N, Jeyamurugan R, Senthilkumar R, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：在Ehrlich腹水癌肿瘤模型中体内和对高度特异性硫醇载体载体铜（II）和锌（II）复合物的体内评价。
4. Chitosan- Copper(II) , Zinc(II) and Ferric(II) Complexes as Antimicrobial Agent: Synthesis, Characterization and Structure- Activity Study [C] . Xiaohui Wang, Yumin Du, Fei Huang Polymeric Materials: Science Engineering Symposia . 2005

机译：壳聚糖 - 铜（II），锌（II）和铁（II）复合物作为抗微生物剂：合成，表征和结构 - 活性研究
5. The synthesis, characterization, and antitumor properties of silver(I), copper(II), and rhodium(III) metal complexes. [D] . Medvetz, Doug A. 2008

机译：银（I），铜（II）和铑（III）金属配合物的合成，表征和抗肿瘤性能。
6. Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity [O] . Vesna Milacic, Di Chen, Lorena Giovagnini, -1

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7. In vitro and in vivo evaluation of antitumor activity of methanolic extract of Argyreia nervosa leaves on Ehrlich ascites carcinoma [O] . Bhawna Sharma, Isha Dhamija, Sandeep Kumar, 2015

机译：体外和体内评价神经节细胞药物甲醇提取物对艾氏腹水癌的抗肿瘤活性
8. Synthesis and Properties of Homonuclear Dimetallic Nickel(II), Copper(II) and Zinc(II) Complexes of p-Xylenediyl and 2-Butynediyl-Bridged Dicyclenes. [R] . Crane, C. G., Burrows, C. J. 1993

机译：对二甲苯二基和2-丁二基桥连二环的双核二聚镍（II），铜（II）和锌（II）配合物的合成和性质。

In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model.

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