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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Crystal structures, DNA-binding and cytotoxic activities studies of Cu(II) complexes with 2-oxo-quinoline-3-carbaldehyde Schiff-bases.
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Crystal structures, DNA-binding and cytotoxic activities studies of Cu(II) complexes with 2-oxo-quinoline-3-carbaldehyde Schiff-bases.

机译：Cu（II）复合物的晶体结构，DNA结合和细胞毒性活性研究用2-氧代喹啉-3-咔醛席基底座。

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摘要

Three novel 2-oxo-quinoline-3-carbaldehyde Schiff-bases and their Cu(II) complexes were synthesized. The molecular structures of Cu(II) complexes were determined by X-ray crystal diffraction. The DNA-binding modes of the complexes were also investigated by UV-vis absorption spectrum, fluorescence spectrum, viscosity measurement and EB-DNA displacement experiment. The experimental evidences indicated that the ligands and Cu(II) complexes could interact with CT-DNA (calf-thymus DNA) through intercalation, respectively. Comparative cytotoxic activities of ligands and Cu(II) complexes were also determined by MTT [3-(4,5-dimethyl-2-thiazoyl)-2,5-diphenyl-2H-tetrazolium bromide] and SRB (sulforhodamine B) methods. The results showed that the three Cu(II) complexes exhibited more effective cytotoxic activity against HL60 cells and HeLa cells than corresponding ligands. Also, CuL(3) showed higher cytotoxic activity than CuL(1) and CuL(2).
机译：合成了三种新型的2-氧代喹啉-3-克巴甲醛Schiff-碱基及其Cu（II）配合物。 通过X射线晶体衍射测定Cu（II）复合物的分子结构。 还通过UV-Vis吸收光谱，荧光光谱，粘度测量和EB-DNA位移实验研究了复合物的DNA结合模式。 实验证据表明，配体和Cu（II）复合物可以分别与CT-DNA（CALF-Thymus DNA）相互作用。 通过MTT [3-（4,5-二甲基-2-噻唑）-2,5-二苯基-2H-四唑溴化物]和SRB（苏尔磺胺胺B）方法也测定配体和Cu（II）配合物的比较细胞毒性活性。 结果表明，三种Cu（II）复合物对HL60细胞和HeLa细胞的更有效的细胞毒性活性比相应的配体。 此外，CUL（3）表现出高于CUL（1）和CUL（2）的细胞毒性活性。

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