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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Crystal structures, DNA-binding and cytotoxic activities studies of Cu(II) complexes with 2-oxo-quinoline-3-carbaldehyde Schiff-bases.
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Crystal structures, DNA-binding and cytotoxic activities studies of Cu(II) complexes with 2-oxo-quinoline-3-carbaldehyde Schiff-bases.

机译：具有2-氧代喹啉-3-甲醛甲醛席夫碱的Cu（II）配合物的晶体结构，DNA结合和细胞毒性活性研究。

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摘要

Three novel 2-oxo-quinoline-3-carbaldehyde Schiff-bases and their Cu(II) complexes were synthesized. The molecular structures of Cu(II) complexes were determined by X-ray crystal diffraction. The DNA-binding modes of the complexes were also investigated by UV-vis absorption spectrum, fluorescence spectrum, viscosity measurement and EB-DNA displacement experiment. The experimental evidences indicated that the ligands and Cu(II) complexes could interact with CT-DNA (calf-thymus DNA) through intercalation, respectively. Comparative cytotoxic activities of ligands and Cu(II) complexes were also determined by MTT [3-(4,5-dimethyl-2-thiazoyl)-2,5-diphenyl-2H-tetrazolium bromide] and SRB (sulforhodamine B) methods. The results showed that the three Cu(II) complexes exhibited more effective cytotoxic activity against HL60 cells and HeLa cells than corresponding ligands. Also, CuL(3) showed higher cytotoxic activity than CuL(1) and CuL(2).
机译：合成了三种新型的2-氧代喹啉-3-甲醛席夫碱及其Cu（II）配合物。通过X射线晶体衍射确定Cu（II）配合物的分子结构。还通过紫外可见吸收光谱，荧光光谱，粘度测量和EB-DNA置换实验研究了配合物的DNA结合模式。实验证据表明，配体和Cu（II）配合物可以分别通过嵌入与CT-DNA（小牛胸腺DNA）相互作用。还通过MTT [3-（4,5-二甲基-2-噻唑基）-2,5-二苯基-2H-溴化四唑]和SRB（磺胺丁丹B）方法确定了配体和Cu（II）配合物的比较细胞毒性。结果表明，这三种Cu（II）配合物对HL60细胞和HeLa细胞显示出比相应配体更有效的细胞毒活性。此外，CuL（3）显示出比CuL（1）和CuL（2）高的细胞毒性活性。

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