Design and synthesis of alpha-phenoxy-N-sulfonylphenyl acetamides as Trypanosoma brucei Leucyl-tRNA synthetase inhibitors

著录项

• 来源
  《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2020年第2020期|共10页
• 作者

  Xin Weixiang; Li Zezhong; Wang Qing; Du Jin; Zhu Mingyan; Zhou Huchen;

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• 作者单位

  Shanghai Jiao Tong Univ Sch Pharm State Key Lab Microbial Metab Shanghai 200240 Peoples R China;

  Shanghai Jiao Tong Univ Sch Pharm State Key Lab Microbial Metab Shanghai 200240 Peoples R China;

  Shanghai Jiao Tong Univ Sch Pharm State Key Lab Microbial Metab Shanghai 200240 Peoples R China;

  Shanghai Jiao Tong Univ Sch Pharm State Key Lab Microbial Metab Shanghai 200240 Peoples R China;

  Shanghai Jiao Tong Univ Sch Pharm State Key Lab Microbial Metab Shanghai 200240 Peoples R China;

  Shanghai Jiao Tong Univ Sch Pharm State Key Lab Microbial Metab Shanghai 200240 Peoples R China;

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• 收录信息
• 原文格式 PDF
• 正文语种 eng
• 中图分类 药学;
• 关键词

  Human African trypanosomiasis (HAT); Anti-trypanosomal agent; Leucyl-tRNA synthetase (LeuRS); alpha-phenoxy-N-Sulfonyiphenyl acetamides; Structure-activity relationship;

  机译：人类非洲胰蛋白酶体（帽子）;抗锥体质剂;脱氨基-TRNA合成酶（Leurs）;α-苯氧基 - 正磺酰苯基乙酰胺;结构 - 活性关系;