PVP intercalated metallic WSe2 as NIR photothermal agents for efficient tumor ablation

Moses Oyawale Adetunji; Khan Malik Ihsanullah; Fang Qi; Qin Liu; Rehman Zia Ur; Zhang Youkui; Feng Cao Deng; Ma Yinchu; Tang XinFeng; Wu Chuanqiang; Adam Mukhtar Lawan; Huang Dake; Liu Hang; Song Li

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PVP intercalated metallic WSe2 as NIR photothermal agents for efficient tumor ablation

机译：PVP插层金属WSE2作为NIR光热试剂用于有效肿瘤消融

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Transition metal dichalogenides (TMDCs) with unique layered structures hold promising potential as transducers for photothermal therapy. However, the low photothermal conversion efficiency and poor stability in some cases limit their practical applications. Herein, we demonstrate the fabrication of ultrathin homogeneous hybridized TMDC nanosheets and their use for highly efficient photothermal tumor ablation. In particular, the nanosheets were composed of metallic WSe2 intercalated with polyvinylpyrrolidone (PVP), which was facilely prepared through a solvothermal process from the mixture of selenourea crystals, WCl6 powder along with PVP polymeric nanogel. Our characterizations revealed that the obtained nanosheets exhibited excellent photothermal conversion efficiency, therapeutic demonstration with improved biocompatibility and physiological stability attributing to the combined merits of metallic phase of WSe2 and hydrophilic PVP insertion. Both the histological analysis of vital organs and in vitro/in vivo tests confirmed the nanosheets as actively effective and biologically safe in this phototherapeutic technique. Findings from this non-invasive experiment clearly emphasize the explorable therapeutic efficacy of the layered-based hybrid agents in future cancer treatment planning procedures.

机译：具有独特分层结构的过渡金属二硫烷物（TMDC）保持有希望的电位作为光热疗法的换能器。然而，在某些情况下，低温转化效率和稳定性差限制了它们的实际应用。在此，我们证明了超薄均匀杂交TMDC纳米片的制备及其用于高效的光热肿瘤消融。特别地，纳米片由与聚乙烯基吡咯烷酮（PVP）嵌入的金属WSE2组成，其通过从Selenourea晶体的混合物，WCL6粉末以及PVP聚合物纳米凝胶的溶剂热法制备。我们的特征揭示了所获得的纳米片表现出优异的光热转化效率，治疗展示，具有改善的生物相容性和归因于WSe2和亲水PVP插入的组合优点的生物相容性和生理稳定性。重要器官和体内测试的组织学分析既确认纳米蛋白酶在这种光治疗技术中积极有效和生物学安全。来自这种非侵入性实验的调查结果清楚地强调了在未来的癌症治疗计划程序中的分层杂合剂的可扩展治疗疗效。

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来源
《Nanotechnology》 |2019年第6期|共10页
作者
Moses Oyawale Adetunji; Khan Malik Ihsanullah; Fang Qi; Qin Liu; Rehman Zia Ur; Zhang Youkui; Feng Cao Deng; Ma Yinchu; Tang XinFeng; Wu Chuanqiang; Adam Mukhtar Lawan; Huang Dake; Liu Hang; Song Li;
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Univ Sci &

Technol China CAS Ctr Excellence Nanosci Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China;

Univ Sci &

Technol China Sch Life Sci Hefei 230027 Anhui Peoples R China;

Univ Sci &

Technol China CAS Ctr Excellence Nanosci Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China;

Univ Sci &

Technol China CAS Ctr Excellence Nanosci Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China;

Univ Sci &

Technol China CAS Ctr Excellence Nanosci Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China;

Univ Sci &

Technol China CAS Ctr Excellence Nanosci Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China;

Univ Sci &

Technol China CAS Ctr Excellence Nanosci Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China;

Univ Sci &

Technol China Sch Life Sci Hefei 230027 Anhui Peoples R China;

Univ Sci &

Technol China Sch Life Sci Hefei 230027 Anhui Peoples R China;

Univ Sci &

Technol China CAS Ctr Excellence Nanosci Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China;

Univ Sci &

Technol China CAS Ctr Excellence Nanosci Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China;

Anhui Med Univ Basic Med Coll Hefei 230032 Anhui Peoples R China;

Univ Sci &

Technol China Sch Life Sci Hefei 230027 Anhui Peoples R China;

Univ Sci &

Technol China CAS Ctr Excellence Nanosci Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China;

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正文语种 eng
中图分类特种结构材料;
关键词
solvothermal synthesis; metallic tungsten diselenide; intercalation; photothermal therapy; photothermal conversion effeciency;

机译：溶剂质合成;金属钨酶;插层;光热疗法;光热转换效率;

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专利

1. PVP intercalated metallic WSe2 as NIR photothermal agents for efficient tumor ablation [J] . Moses Oyawale Adetunji, Khan Malik Ihsanullah, Fang Qi, Nanotechnology . 2019,第6期

机译：PVP插层金属WSE2作为NIR光热试剂用于有效肿瘤消融
2. A cruciform phthalocyanine pentad-based NIR-II photothermal agent for highly efficient tumor ablation [J] . Houhe Pan, Shukun Li, Jing-lan Kan, Chemical science . 2019,第35期

机译：十字形酞菁五单元组的NIR-II光热剂，用于高效消融肿瘤
3. Dendrimer-Templated Ultrasmall and Multifunctional Photothermal Agents for Efficient Tumor Ablation [J] . Zhou Zhengjie, Wang Yitong, Yan Yang, ACS nano . 2016,第4期

机译：树状聚合物模板的超小型和多功能光热剂，可有效消融肿瘤。
4. A Minimally Invasive Multifunctional Nanoscale System for Selective Targeting, Imaging, and NIR Photothermal Therapy of Malignant Tumors [C] . H.N. Green, D.V. Martyshkin, E.L. Rosenthal, Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications III . 2011

机译：用于恶性肿瘤的选择性靶向，成像和NIR光热疗法的微创多功能纳米系统。
5. Nanoshell-assisted cancer therapy: Targeted photothermal tumor ablation. [D] . Lowery, Amanda Raley. 2007

机译：纳米壳辅助癌症治疗：靶向光热肿瘤消融。
6. A cruciform phthalocyanine pentad-based NIR-II photothermal agent for highly efficient tumor ablation [O] . Houhe Pan, Shukun Li, Jing-lan Kan, 2019

机译：基于十字形酞菁五单元组的NIR-II光热剂用于高效消融肿瘤
7. A cruciform phthalocyanine pentad-based NIR-II photothermal agent for highly efficient tumor ablation [O] . Houhe Pan, Shukun Li, Jing-lan Kan, 2019

机译：基于十字形的酞菁氨基胺的NIR-II光热试剂，用于高效肿瘤烧蚀

PVP intercalated metallic WSe2 as NIR photothermal agents for efficient tumor ablation

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