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A poly(hydroxyethyl methacrylate)-Ag nanoparticle porous hydrogel for simultaneous in vivo prevention of the foreign-body reaction and bacterial infection

机译：聚（羟乙基甲基丙烯酸酯）纳米颗粒多孔水凝胶，用于同时预防异物反应和细菌感染

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摘要

The use of implants or indwelling medical devices has greatly enhanced the quality and efficacy of health care. However, foreign-body reactions (FBRs) and infections can lead to potential failure or removal of the devices, or increased morbidity and mortality of patients. Herein, we develop a silver nanoparticle (AgNP) loaded poly(hydroxyethyl methacrylate) hydrogel with spherical, interconnected 40 mu m pores. The resulting hydrogels displayed good antibacterial properties regarding both gram positive bacteria (Staphylococcus aureus) and gram negative bacteria (Escherichia coli (E. coli)) in vitro and were highly efficient at inhibiting bacterial cell growth. Moreover, they exhibited an in vivo resistance to FBRs by reducing the immune responses, and completely prevented the formation of collagen capsules. Finally, in vivo studies of the E. coli infected mouse model demonstrated that the AgNP loaded porous hydrogels were highly efficient at resisting the bacterial FBRs and infections, while they promoted cell mitigation and infiltration. Findings from this work suggest that AgNP loaded porous hydrogels hold promise in various biomedical applications including in the new generation of implantable biomedical devices and tissue engineering scaffolds.
机译：使用植入物或留置医疗器械的使用大大提高了保健的质量和功效。然而，异物反应（FBRS）和感染可能导致潜在的失败或取消装置，或增加患者的发病率和死亡率。在此，我们用球形，开发银纳米颗粒（AgNP）负载的聚（羟乙基甲基丙烯酸酯）水凝胶，互连40μm孔。所得水凝胶显示有关于革兰氏阳性细菌（金黄色葡萄球菌）和革兰氏阴性细菌（大肠杆菌（大肠杆菌））的良好抗菌性能，并且在抑制细菌细胞生长时具有高效。此外，它们通过降低免疫应答而对FBR进行体内抗性，并完全阻止形成胶原胶囊。最后，在大肠杆菌感染的小鼠模型的体内研究表明，AgNP加载的多孔水凝胶在抵抗细菌FBRS和感染时高效，同时促进细胞缓解和渗透。从这项工作的调查结果表明，AGNP装载多孔水凝胶在各种生物医学应用中拥有承诺，包括在新一代可植入生物医学装置和组织工程支架中。

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