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Influence of silver content on rifampicin adsorptivity for magnetite/Ag/rifampicin nanoparticles

机译：银含量对磁铁矿/ AG /利福平纳米粒子利福平腺体吸附性的影响

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摘要

Magnetite nanoparticles (NPs) decorated with silver (magnetite/Ag) are intensively investigated due to their application in the biomedical field. We demonstrate that the increase of silver content on the surface of nanoparticles improves the adsorptivity of antibiotic rifampicin as well as antibacterial properties. The use of ginger extract allowed to improve the silver nucleation on the magnetite surface that resulted in an increase of silver content. Physicochemical and functional characterization of magnetite/Ag NPs was performed. Our results show that 5%-10% of silver content in magnetite/Ag NPs is already sufficient for antimicrobial properties against Streptococcus salivarius and Staphylococcus aureus. The rifampicin molecules on the magnetite/Ag NPs surface made the spectrum of antimicrobial activity wider. Cytotoxicity evaluation of the magnetite/Ag/rifampicin NPs showed no harmful action towards normal human fibroblasts, whereas the effect on human embryonic kidney cell viability was time and dose dependent.
机译：由于其在生物医学领域的应用，用银（磁铁矿/ AG）装饰的磁铁矿纳米粒子（NPS）被密集地调查。我们证明纳米颗粒表面上银含量的增加改善了抗生素利福平以及抗菌性能的吸附性。使用姜提取物使得改善磁铁矿表面上的银成核，导致银含量增加。进行磁铁矿/ Ag NP的物理化学和功能表征。我们的研究结果表明，磁铁矿/ Ag NPS中的5％-10％的银含量已经足以针对链球菌和金黄色葡萄球菌的抗微生物性质。磁铁矿/ Ag NPS表面上的利福平分子使抗微生物活性宽的光谱。磁铁矿/ Ag /利福平NPS的细胞毒性评价显示对正常人体成纤维细胞没有有害作用，而对人胚胎肾细胞活力的影响是时间和剂量依赖性。

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  • 来源
    《Nanotechnology》 |2017年第5期|共11页
  • 作者

    Ivashchenko Olena; Coy Emerson; Peplinska Barbara; Jarek Marcin; Lewandowski Mikolaj; Zaleski Karol; Warowicka Alicja; Wozniak Anna; Babutina Tatiana; Jurga-Stopa Justyna; Dolinsek Janez; Jurga Stefan;

  • 作者单位

    Adam Mickiewicz Univ NanoBioMed Ctr 85 Umultowska St PL-61614 Poznan Poland;

    Adam Mickiewicz Univ NanoBioMed Ctr 85 Umultowska St PL-61614 Poznan Poland;

    Adam Mickiewicz Univ NanoBioMed Ctr 85 Umultowska St PL-61614 Poznan Poland;

    Adam Mickiewicz Univ NanoBioMed Ctr 85 Umultowska St PL-61614 Poznan Poland;

    Adam Mickiewicz Univ NanoBioMed Ctr 85 Umultowska St PL-61614 Poznan Poland;

    Adam Mickiewicz Univ NanoBioMed Ctr 85 Umultowska St PL-61614 Poznan Poland;

    Adam Mickiewicz Univ NanoBioMed Ctr 85 Umultowska St PL-61614 Poznan Poland;

    Adam Mickiewicz Univ NanoBioMed Ctr 85 Umultowska St PL-61614 Poznan Poland;

    NAS Ukraine Frantsevich Inst Problems Mat Sci Kiev Ukraine;

    Poznan Univ Med Sci Dept Biomat &

    Expt Dent Poznan Poland;

    Jozef Stefan Inst Dept Solid State Phys Ljubljana Slovenia;

    Adam Mickiewicz Univ NanoBioMed Ctr 85 Umultowska St PL-61614 Poznan Poland;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种结构材料;
  • 关键词

    magnetite; silver; ginger; rifampicin;

    机译：磁铁矿;银;生姜;利福平;

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