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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Individual differences in the brain are associated with resilience versus susceptibility to lipopolysaccharide-induced memory impairment
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Individual differences in the brain are associated with resilience versus susceptibility to lipopolysaccharide-induced memory impairment

机译：大脑中的个体差异与脂多糖引起的血清多糖引起的记忆障碍的韧性与易感性相关

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摘要

Sepsis impairs learning and memory function, yet marked interindividual variability exists in the degree to which sepsis compromises learning and memory function. Thus, testing resilience versus susceptibility to systemic inflammation induced-memory impairment and the underlying mechanism is needed. In the present study, we firstly used lipopolysaccharide (LPS) to induce memory impairment, and then evaluated cognitive function on days 4-7 after the first LPS challenge. Subjects' scores on both behavioral measures were subjected to a hierarchical cluster analysis, identifying two clusters that differed notably on the Y-maze and fear conditioning tests. This analysis divided these subjects into two groups, one cluster (13 of 34 subjects) displayed impaired working and associative memory, named "Susceptive". The remaining cluster (21 of 34 subjects) showed normal memory, named "Resilient". We have also included another group receiving normal saline to serve as the control group. The three groups underwent a battery of biochemical detections. In addition, we investigated whether the individual differences would disappear between the "Resilient" and "Susceptive" groups by using microglia inhibitor minocycline. We showed that as compared with the "Resilient" or control group, the "Susceptive" group was accompanied by increased tumor necrosis factor-alpha, interleukin-1beta (IL-1 beta), IL-6, and biomarkers of microglia activation ionized calcium binding adaptor molecule-1 and cluster of differentiation 68. Notably, after decreasing the activation of microglia, the differences in cognitive function between the "Resilient" and "Susceptive" groups disappeared. Collectively, our study suggests that individual differences in the brain are associated with resilience versus susceptibility to LPS-induced memory impairment.
机译：Sepsis损害学习和记忆功能，但SEPSIS妥协学习和内存功能的程度存在标记的接口变异性。因此，需要测试弹性与系统性炎症诱导记忆障碍的易感性和潜在机制。在本研究中，我们首先使用脂多糖（LPS）诱导记忆障碍，然后在第一个LPS挑战后的第4-7天评估认知功能。对两种行为措施的主题分数进行了分层聚类分析，识别两个簇，特别是在Y迷宫和恐惧调理试验上不同。该分析将这些受试者分为两组，一个集群（34个受试者的13个）显示了工作受损和联想记忆，名为“易受侦查”。剩下的群集（34个受试者的21个）显示正常的内存，名为“弹性”。我们还包括接受正常盐水的另一组作为对照组。三组经历了生化检测的电池。此外，我们研究了通过使用微胶质细胞抑制剂米诺环素，各个差异是否在“弹性”和“易感性”组之间消失。我们表明，与“弹性”或对照组相比，“易患”组伴随着肿瘤坏死因子-α，白细胞介素-1beta（IL-1β），IL-6和微胶质细胞活化电离钙的生物标志物结合适配器分子-1和分化簇68.值得注意的是，在降低微胶质细胞的激活后，“弹性”和“易感性”组之间的认知功能的差异消失。统称，我们的研究表明大脑中的个体差异与对LPS引起的内存损伤的易感性相关。

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