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首页> 外文期刊>New Journal of Chemistry >Synthesis, photophysics and biomolecule interactive studies of new hybrid benzo-2,1,3-thiadiazoles
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Synthesis, photophysics and biomolecule interactive studies of new hybrid benzo-2,1,3-thiadiazoles

机译：新型杂交苯并-2,1,3-噻唑的合成，光药和生物分子互动研究

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摘要

Four new hybrid molecules containing benzo-2,1,3-thiadiazole, benzofuran and arylselanyl moieties, named 4,7-bis(3-(arylselanyl)benzofuran-2-yl)benzo[c][1,2,5]thiadiazoles, were designed and synthesized in good yields through an electrophilic cyclization of 4,7-bis((2-methoxyphenyl)ethynyl)benzo[c][1,2,5]thiadiazole 1 and diaryl diselenides 2 using trichloroisocyanuric acid to generate electrophilic arylselanyl species. The photophysical properties of compounds 3a-d were investigated using UV-vis absorption and emission fluorescence analysis. The emission fluorescence analysis showed a yellow-orange region emission. Large Stokes shift values were observed for all new derivatives and attributed to the ICT state and to the electron-substituent properties. The biomolecule-binding DNA and HSA-binding interactions were also investigated by experimental and theoretical methods.
机译：含有苯并-2,1,3-噻二唑，苯并呋喃和芳基脲部分的四种新的杂种分子，名为4,7-双（3-（芳基）苯并呋喃-2-基）苯并[C] [1,2,5]噻二唑 通过使用三氯异氰脲酸的4,7-Bis（（2-甲氧基苯基）乙炔基）苯并[C] [1,2,5]噻二唑1和二芳基二唑1和二芳基二唑1和二芳基甲醚2的亲电环化设计和合成。用三氯异氰脲酸产生电泳芳基苯胺基 物种。 使用UV-Vis吸收和发射荧光分析研究了化合物3A-D的光物理性质。 发射荧光分析显示出黄橙区域排放。 为所有新衍生物观察到大的斯托克斯换档值，并归因于ICT状态和电子取代基特性。 还通过实验和理论方法研究了生物分子结合DNA和HSA结合相互作用。

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  • 来源
    《New Journal of Chemistry》 |2020年第7期|共13页
  • 作者

    Neto Jose S. S.; Kruger Roberta; Balaguez Renata A.; Fronza Mariana G.; Acunha Thiago V; Oliboni Robson S.; Savegnago Lucielli; Iglesias Bernardo A.; Alves Diego;

  • 作者单位

    Univ Fed Pelotas UFPel Lab Sintese Organ Limpa POB 354 BR-96010900 Pelotas RS Brazil;

    Univ Fed Pelotas UFPel Lab Sintese Organ Limpa POB 354 BR-96010900 Pelotas RS Brazil;

    Univ Fed Pelotas UFPel Lab Sintese Organ Limpa POB 354 BR-96010900 Pelotas RS Brazil;

    Univ Fed Pelotas UFPel PPGB GPN BR-96010900 Pelotas RS Brazil;

    Univ Fed Santa Maria Lab Bioinorgan &

    Mat Porfirin Dept Chem BR-97115900 Santa Maria RS Brazil;

    Univ Fed Pelotas UFPel Grp Catalise &

    Estudos Teor BR-96010900 Pelotas RS Brazil;

    Univ Fed Pelotas UFPel PPGB GPN BR-96010900 Pelotas RS Brazil;

    Univ Fed Santa Maria Lab Bioinorgan &

    Mat Porfirin Dept Chem BR-97115900 Santa Maria RS Brazil;

    Univ Fed Pelotas UFPel Lab Sintese Organ Limpa POB 354 BR-96010900 Pelotas RS Brazil;

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  • 正文语种 eng
  • 中图分类 化学;
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