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首页> 外文期刊>New Journal of Chemistry >Preparation and properties of a biodegradable poly(lactide-co-glycolide)/poly(trimethylene carbonate) porous composite scaffold for bone tissue engineering
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Preparation and properties of a biodegradable poly(lactide-co-glycolide)/poly(trimethylene carbonate) porous composite scaffold for bone tissue engineering

机译：可生物降解的聚（丙交酯 - 共乙酰基）/聚（三亚亚亚亚亚乙酯）多孔复合支架用于骨组织工程的制备及性能

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摘要

Herein, a technique for the preparation of a new poly(lactide-co-glycolide) (PLGA)/poly(trimethylene carbonate) (PTMC) composite porous polymeric structure involving blending polymers with salt particlesviafreeze-drying/particulate leaching was developed. This developed technique combined the advantages of both the solution freeze-drying and particulate leaching techniques. The polymer-salt composite was processed using the corresponding method in devices with various shapes and sizes, which could subsequently be extracted to yield the desired porous structures. The effects of different preparation conditions on the properties of the microstructures, connectivity, porosity and compressible strength of the composites were investigated. Depending on the preparatory conditions, including the salt proportion and solution concentration, the resulting porosity of the porous structure was in the range of 80-98%, and the compression strength of the composite varied in the range of 0.56 MPa to 7.98 MPa. Moreover, the cell proliferation results confirmed that the porous polymeric scaffold exhibited good biocompatibility. Consequently, the results indicated that 85 wt% NaCl and 20 w/v% solution concentration were the optimum conditions to achieve the best mechanical enhancement effect andin vitrobioactivity, suggesting that this composite has great potential to be used as a bone repair material in the future.
机译：在此，开发了一种用于制备新的聚（丙交酯 - 共乙酰化）（PLGA）/聚（三甲基碳酸酯）（PTMC）复合多孔多孔聚合物结构的技术，涉及与盐分解干燥/颗粒浸出的共混聚合物。这种开发技术结合了溶液冷冻干燥和颗粒浸出技术的优点。使用具有各种形状和尺寸的装置中的相应方法加工聚合物 - 盐复合物，随后可以提取其提取以产生所需的多孔结构。研究了不同制备条件对复合材料微观结构，连通性，孔隙率和可压缩强度的性能的影响。取决于预备条件，包括盐比例和溶液浓度，所得多孔结构的孔隙率在80-98％的范围内，复合材料的压缩强度在0.56MPa至7.98MPa的范围内变化。此外，细胞增殖结果证实，多孔聚合物支架表现出良好的生物相容性。因此，结果表明，85wt％NaCl和20w / v％溶液浓度是实现最佳机械增强效果的最佳条件，旨在使该复合材料具有巨大的潜力将来用作骨修补材料。

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  • 来源
    《New Journal of Chemistry》 |2020年第34期|共10页
  • 作者

    Qi Jin; Zhang Yu; Liu Xiliang; Zhang Qianmao; Xiong Chengdong;

  • 作者单位

    Chinese Acad Sci Chengdu Inst Organ Chem Chengdu 610041 Peoples R China;

    Chinese Acad Sci Chengdu Inst Organ Chem Chengdu 610041 Peoples R China;

    Chinese Acad Sci Chengdu Inst Organ Chem Chengdu 610041 Peoples R China;

    Chinese Acad Sci Chengdu Inst Organ Chem Chengdu 610041 Peoples R China;

    Chinese Acad Sci Chengdu Inst Organ Chem Chengdu 610041 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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