Facile oxidative cyclization to access C2-quaternary 2-hydroxy-indolin-3-ones: synthetic studies towards matemone

Wen Sai-Shuai; Zhou Zhao-Fang; Xiao Jun-An; Li Jun; Xiang Haoyue; Yang Hua

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Facile oxidative cyclization to access C2-quaternary 2-hydroxy-indolin-3-ones: synthetic studies towards matemone

机译：容易氧化环化以获得C2-季 - 羟基 - 吲哚-3-吲哚-3-吲哚 - 吲哚 - 3- in-ins：对Matemone的合成研究

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A concise and facile approach for the construction of 2-hydroxy-2-substituted indol-3-ones was developed through an oxidative cyclization of 2-aminophenyl-1,3-dione. Using CAN and TEMPO as oxidants, C2-quaternary 2-hydroxy-indolin-3-ones were efficiently installed in moderate to excellent yields (up to 99%). Moreover, this developed protocol was further applied to synthetic studies towards natural product matemone by starting from readily available 2-amino-4-bromobenzoic acid, and the precursor for matemone was efficiently installed.

机译：通过2-氨基苯基-1,3-二酮的氧化环化，通过2-氨基苯基-1,3-二酮构建建造2-羟基-2取代的Indol-3-施工的简洁和容易的方法。使用CAN和TEMPO作为氧化剂，C2-季铵2-羟基 - 吲哚林-3- 3-吲哚-3-吲哚-3-吲哚-3- inte indegry and ut offerse（高达99％）。此外，通过从易于使用的2-氨基-4-溴苯甲酸开始，该开发方案进一步应用于天然产物Matemone的合成研究，并且有效地安装了Matemone的前体。

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来源
《New Journal of Chemistry》 |2017年第20期|共4页
作者
Wen Sai-Shuai; Zhou Zhao-Fang; Xiao Jun-An; Li Jun; Xiang Haoyue; Yang Hua;
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作者单位

Cent S Univ Coll Chem &

Chem Engn Changsha 410083 Hunan Peoples R China;

Cent S Univ Coll Chem &

Chem Engn Changsha 410083 Hunan Peoples R China;

Guangxi Teachers Educ Univ Coll Chem &

Mat Sci Nanning 530001 Guangxi Peoples R China;

Cent S Univ Coll Chem &

Chem Engn Changsha 410083 Hunan Peoples R China;

Cent S Univ Coll Chem &

Chem Engn Changsha 410083 Hunan Peoples R China;

Cent S Univ Coll Chem &

Chem Engn Changsha 410083 Hunan Peoples R China;

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正文语种 eng
中图分类化学;
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1. Facile oxidative cyclization to access C2-quaternary 2-hydroxy-indolin-3-ones: synthetic studies towards matemone [J] . Wen Sai-Shuai, Zhou Zhao-Fang, Xiao Jun-An, New Journal of Chemistry . 2017,第20期

机译：容易氧化环化以获得C2-季 - 羟基 - 吲哚-3-吲哚-3-吲哚 - 吲哚 - 3- in-ins：对Matemone的合成研究
2. Asymmetric epoxidation of 2-arylidene-1,3-diketones: facile access to synthetically useful epoxides [J] . Alessio Russo, Alessandra Lattanzi Organic & biomolecular chemistry . 2010,第11期

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Facile oxidative cyclization to access C2-quaternary 2-hydroxy-indolin-3-ones: synthetic studies towards matemone

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