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首页> 外文期刊>Life sciences >Association of single nucleotide polymorphisms of nicotinic acetylcholine receptor subunits with cervical neoplasia.
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Association of single nucleotide polymorphisms of nicotinic acetylcholine receptor subunits with cervical neoplasia.

机译：烟碱乙酰胆碱受体亚基与宫颈瘤的缔合物的缔合核苷酸多态性。

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摘要

Cholinergic signaling, particularly in response to non-physiological ligands like nicotine, stimulates carcinogenesis of a variety of tissue types including epithelia of the cervix uteri. Cholinergic signaling is mediated by nicotinic acetylcholine receptors (nAChRs), which are pentamers formed by subsets of 16 nAChR subunits. Recent literature suggests that single nucleotide polymorphisms (SNPs) of some of these subunits, notably alpha5, are risk factors for developing lung cancer in smokers as well as in non-smokers.We have studied the prevalence of four SNPs in the alpha5, alpha9, and beta1 subunits, which are expressed in cervical cells, in 456 patients with cervical cancers, precursor lesions, and healthy controls from two cohorts in Mexico.A SNP in the alpha9 subunit, the G allele of rs10009228 (alpha9, A>G) shows a significant trend in the combined cohort, indicating that this allele constitutes a risk factor for neoplastic progression. The A allele of the SNP rs16969968 (alpha5, G>A), which correlates with the development of lung cancer, shows a non-significant trend to be associated with cervical lesions. Two other SNPs, rs55633891 (alpha9, C>T) and rs17856697 (beta1, A>G), did not exhibit a significant trend.Our study points to a potential risk factor of cervical carcinogenesis with importance for DNA diagnosis and as a target for intervention.
机译：胆碱能信号，特别是响应尼古丁等非生理配体，刺激各种组织类型的致癌，包括宫颈子宫的上皮细胞。胆碱能信号传导由烟碱乙酰胆碱受体（NACHRS）介导，其是由16个NACHR亚基的子集形成的五聚体。最近的文献表明，这些亚基的一些核苷酸多态性（SNP），特别是α5，是在吸烟者和非吸烟者中培养肺癌的危险因素。我们已经研究过alpha5，alpha9中的四个SNP的患病率。和β1亚基，其在宫颈细胞中表达，在456名宫颈癌，前体病变和来自墨西哥群组的两个队列的健康对照中。在α9亚基的SNP中，Rs10009228的g等位基因（alpha9，a> g）显示联合队列的重要趋势，表明该等位基因构成肿瘤进展的危险因素。 SNP RS16969968（alpha5，g> a）的等位基因与肺癌的发育相关，表明与宫颈病变有关的非显着趋势。另外两种SNP，RS55633891（Alpha9，C> T）和RS17856697（Beta1，A> G）没有表现出显着的趋势。我们研究指出宫颈癌的潜在危险因素，具有重要的DNA诊断和目标干涉。

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