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首页> 外文期刊>Life sciences >Muscle sarcomas and alopecia in A/J mice chronically treated with nicotine.
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Muscle sarcomas and alopecia in A/J mice chronically treated with nicotine.

机译：用尼古丁慢性治疗的A / J小鼠的肌肉肉瘤和Alopecia。

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To evaluate the pathobiologic effects of long-term treatment with nicotine of A/J mice susceptible to tobacco-induced lung carcinogenesis.Experimental group of mice received subcutaneous injections of the LD(50) dose of (-)nicotine hydrogen tartrate of 3 mg/kg/day, 5 days per week for 24 months, and control group received the vehicle phosphate-buffered saline.Nicotine treated mice, 78.6%, but none of control of mice, developed neoplasms originating from the uterus or skeletal muscle. Examination of the uterine neoplasms revealed leiomyosarcomas, composed of whorled bundles of smooth-muscle like cells with large and hyperchromatic nuclei. Sections of the thigh neoplasms revealed densely cellular tumors composed of plump spindle cells, with occasional formation of 'strap' cells, containing distorted striations. Both neoplasms were positive for desmin staining. A solitary pulmonary adenoma with papillary architecture also occurred in one nicotine treated mouse. Experimental mice also developed transient balding starting as small patches of alopecia that progressed to distinct circumscribed areas of complete hair loss or large areas of diffuse hair loss.We demonstrate for the first time that chronic nicotine treatment can induce the development of muscle sarcomas as well as transient hair loss. These findings may help explain the association of childhood rhabdomyosarcoma with parental smoking and earlier onset of balding in smokers. It remains to be determined whether the pathobiologic effects of nicotine result from its receptor-mediated action and/or its tissue metabolites cotinine and N'-nitrosonornicotine, or toxic effects of reactive oxygen species activated due to possible intracellular accumulation of nicotine.
机译：为了评估长期治疗与易受烟草诱导的肺癌癌的尼古丁的病理学效应。小鼠的实验组的皮下注射（50）剂量的（ - ）尼古丁氢气制丁酸类药物3mg /千克/日，每周5天，24个月，对照组接受磷酸盐缓冲盐水。训练疗法治疗小鼠，78.6％，但对小鼠无规，源自子宫或骨骼肌的肿瘤。检查子宫内膜的肿瘤显示平滑肌肉瘤，由具有大而良核的细胞的轮滑肌肉捆扎。大腿肿瘤切片密集显示饱满梭形细胞组成的细胞肿瘤，偶尔形成“带”的细胞，包含失真的条纹。两个肿瘤都是阳性的染色阳性。孤立肺腺瘤，乳头结构也发生在一个尼古丁处理的小鼠中。实验小鼠还开发出瞬态秃顶，开始作为小斑块的小斑块，以便不同的脱发或大型漫射脱发区域的不同的脱毛区域。我们第一次证明慢性尼古丁治疗可以诱导肌肉肉瘤的发展和肌肉肉瘤的发展瞬态脱发。这些发现可能有助于解释儿童横纹肌肉瘤与父母吸烟和吸烟者的秃头发病的关联。仍有待确定尼古丁的病理学作用是否来自其受体介导的作用和/或其组织代谢物Cotinine和N'-硝膦植物，或由于可能的尼古丁可能的细胞内积累而激活的活性氧物种的毒性作用。

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