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Resurgent Na+ current: a new avenue to neuronal excitability control.

机译:复苏NA +电流:新途径对神经元兴奋控制。

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摘要

Integrative and firing properties are important characteristics of neuronal circuits and these responses are determined in large part by the repertoire of ion channels they express, which can vary considerably between cell types. Recently, a new mode of operation of voltage dependent sodium channels has been described that generates a so-called resurgent Na+ current. Accumulating evidence suggests resurgent Na current participates in the generation of sub-threshold inward Na+ current causing membrane depolarization which provides the necessary drive to fire high-frequency action potentials. Recent studies indicate that resurgent Na+ current could be a more widespread feature than previously thought.
机译:一体化和烧制性质是神经元电路的重要特征,并且这些响应由它们表达的离子通道的曲目大部分确定,这可以在细胞类型之间变化很大。 最近,已经描述了一种新的电压相关钠通道的操作模式,其产生所谓的恢复NA +电流。 累积证据表明复苏Na电流参与产生副阈值Na +电流的产生,导致膜去极化,这提供了消除高频动作电位的必要驱动器。 最近的研究表明,复苏Na +电流可能是比以前认为更广泛的特征。

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