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Antidepressant-like effect of gallic acid in mice: Dual involvement of serotonergic and catecholaminergic systems

机译：小鼠中食小酸的抗抑郁作用：血清奈奈和儿茶酚胺能系统的双重累积

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Abstract Aims This study was planned to examine the antidepressant potency of gallic acid (30 and 60mg/kg), a phenolic acid widely distributed in nature, together with its possible underlying monoaminergic mechanisms. Main methods Antidepressant-like activity was assessed using the tail suspension (TST) and the modified forced swimming tests (MFST). Locomotor activity was evaluated in an activity cage. Key findings Administration of gallic acid at 60mg/kg reduced the immobility duration of mice in both the TST and MFST without any changes in the locomotor activity. The anti-immobility effect observed in the TST was abolished with pre-treatment of p -chlorophenylalanine methyl ester (an inhibitor of serotonin synthesis; 100mg/kg i.p. administered for 4-consecutive days), ketanserin (a 5-HT2A/2C antagonist; 1mg/kg i.p.), ondansetron (a 5-HT3 antagonist; 0.3mg/kg i.p.), α-methyl- para -tyrosine methyl ester (an inhibitor of catecholamine synthesis; 100mg/kg i.p.), phentolamine (non-selective alpha-adrenoceptor antagonist; 5mg/kg i.p.), SCH 23390 (a dopamine D1 antagonist; 0.05mg/kg s.c.), and sulpiride (a dopamine D2/D3 antagonist; 50mg/kg i.p.). However, NAN 190 (a 5-HT1A antagonist; 0.5mg/kg i.p.) and propranolol (a non-selective β-adrenoceptor antagonist; 5mg/kg i.p.) pre-treatments were ineffective at reversing the antidepressant-like effects of gallic acid. Significance The results of the present study indicate that gallic acid seems to have a dual mechanism of action by increasing not only serotonin but also catecholamine levels in synaptic clefts of the central nervous system. Further alpha adrenergic, 5-HT2A/2C and 5-HT3 serotonergic, and D1, D2, and D3 dopaminergic receptors also seem to be involved in this antidepressant-like activity.
机译：摘要目的本研究计划检测食药酸（30和60mg / kg）的抗抑郁药效力，酚酸广泛分布在自然界中，以及其可能的单氨基能机制。主要方法使用尾悬架（TST）和改进的强制游泳测试（MFST）评估类似抗抑郁的活性。在活动笼中评估运动活性。键发现在60mg / kg下给予加酸，降低了TST和MFST中小鼠的不动持续时间，而没有运动活性的任何变化。通过预处理对P-氯苯氨基甲烷甲酯（血清素合成的抑制剂;连续4天施用的100mg / kg IP）的预处理被消除了抗身效应，酮柳蛋白（A 5-HT2A / 2C拮抗剂; 1mg / kg IP），ondansetron（5-HT3拮抗剂; 0.3mg / kg IP），α-甲基 - 帕啉甲基酯（儿茶胺合成的抑制剂; 100mg / kg IP），植物植物（非选择性α-肾上腺素依赖者拮抗剂; 5mg / kg IP），SCH 23390（多巴胺D1拮抗剂; 0.05mg / kg sc）和硫脲（多巴胺d2 / d3拮抗剂; 50mg / kg IP）。然而，NaN 190（5-HT1A拮抗剂; 0.5mg / kg I.P.）和丙醇醇（一种非选择性β-肾上腺素受体拮抗剂; 5mg / kg I.p.）预处理在逆转Gallic酸的抗抑郁剂的效果时是无效的。目前研究的结果表明，通过不仅增加血清素，而且在中枢神经系统的突触谱系中的儿茶胺水平增加，加仑酸似乎具有双重作用机制。此外，α肾上腺素能，5-HT2A / 2C和5-HT3 Serotonergic和D1，D2和D3多巴胺能受体也似乎参与了这种类似物的活性。

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