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首页> 外文期刊>RSC Advances >LC-MS-based plasma metabolomics reveals metabolic variations in ovariectomy-induced osteoporosis in female Wistar rats
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LC-MS-based plasma metabolomics reveals metabolic variations in ovariectomy-induced osteoporosis in female Wistar rats

机译：基于LC-MS的血浆代谢组学揭示了女性Wistar大鼠卵巢切除术诱导的骨质疏松症的代谢变化

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摘要

Osteoporosis with a reduction in bone mineral density has become one of the most common metabolic bone diseases. Postmenopausal women are a high-risk group that suffers from osteoporosis when the production of estrogen in their body rapidly declines. Early prediction and diagnosis of osteoporosis will be conducive to having a greater chance to control the deterioration in condition of osteoporosis patients; however, there are still no effective measures in practice. In this study, we aimed at exploring metabolic variations in postmenopausal osteoporosis using ovariectomized female rats as an animal model. The research was performed using liquid chromatography/mass spectrometry (LC/MS) combined with multivariate statistical analysis for plasma metabolome analysis. The results reveal that metabolic variations of ovariectomized-induced osteoporosis involve 18 differentially expressed metabolites and 13 related metabolism pathways such as valine, leucine and isoleucine biosynthesis as well as arachidonic acid and glycerophospholipid metabolism. Notably, the ingenuity pathway analysis platform for further understanding the relationship between metabolic alteration and osteoporosis shows that the change in the levels of metabolites mainly lead to the abnormal state of cellular compromise, cell signaling, inflammation, molecular transport and lipid metabolism. Metabolomics, as a novel way to characterize resolute endogenous small metabolites in organisms, describes the variation in the early stages of metabolic alteration for offering valuable information on pathogenic mechanisms.
机译：骨矿物密度降低的骨质疏松症已成为最常见的代谢骨病之一。绝经后妇女是一种高风险的群体，患骨质疏松症时，当体内的雌激素迅速下降时。早期预测和诊断骨质疏松症将有利于有利于控制骨质疏松患者病情的恶化的机会;但是，实践中仍然没有有效的措施。在这项研究中，我们旨在使用卵巢切除的雌性大鼠作为动物模型来探索绝经后骨质疏松症的代谢变化。使用液相色谱/质谱（LC / MS）与多元统计分析组合进行液相色谱/质谱（LC / MS）进行该研究进行血浆代谢分析。结果表明，卵巢切除诱导的骨质疏松症的代谢变化涉及18个差异表达的代谢物和13个相关的代谢途径，例如缬氨酸，亮氨酸和异亮氨酸生物合成以及花生酸和甘油磷脂代谢。值得注意的是，熟练的途径分析平台进一步了解代谢改变和骨质疏松症之间的关系表明，代谢物水平的变化主要导致细胞折衷，细胞信号传导，炎症，分子运输和脂质代谢的异常状态。代谢组织作为表征综合性内源性小代谢物的新方法，描述了代谢改变的早期阶段的变化，用于提供有关致病机制的有价值信息。

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  • 来源
    《RSC Advances》 |2018年第44期|共10页
  • 作者

    Hu Yan; Zhang Xiaojian; Shan Yu;

  • 作者单位

    Nantong Univ Wujiang Hosp Peoples Hosp Wujiang 1 Clin Lab Suzhou 215200 Peoples R China;

    Nantong Univ Wujiang Hosp Peoples Hosp Wujiang 1 Dept Orthoped Suzhou 215200 Peoples R China;

    Nantong Univ Wujiang Hosp Peoples Hosp Wujiang 1 Dept Orthoped Suzhou 215200 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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