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首页> 外文期刊>RSC Advances >Accelerated fabrication of antibacterial and osteoinductive electrospun fibrous scaffolds via electrochemical deposition
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Accelerated fabrication of antibacterial and osteoinductive electrospun fibrous scaffolds via electrochemical deposition

机译：通过电化学沉积加速了抗菌和骨诱导电纺纤维支架的制备

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摘要

Electrospun fibrous scaffolds have attracted much research interest due to their many applications in orthopedics and other relevant fields. However, poor surface bioactivity of the polymer scaffold body significantly Limits the implementation of many potential applications, and an effective solution remains a great challenge for researchers. Herein, a highly efficient method, namely puked electrochemical deposition (ED) with co-electrospinning nano-Ag dopant, to fabricate poly(L-lactic acid) (PLLA)/nano-Ag composite fibers is presented. The resulting product demonstrated excellent antibacterial properties, as well as strong capabilities in facilitating the precipitation of calcium phosphate crystals at fiber surfaces and in promoting osteogenic differentiation. In the process of ED, the conductivity of the fibers was observed to increase due to the nano-Ag dopant. Upon applying puke signals when charging, water electrolysis occurred in micro-reactive regions of anodic fibers, forming OH-, an alkaline environment that allowed the supersaturation of calcium phosphate. When discharging, the calcium phosphate in the solution diffused rapidly and reduced the concentration polarization, reforming a homogeneous electrolyte. The realization of efficient bioactive coatings at fiber surfaces was achieved in a highly efficient manner by repeating the above charging and discharging processes. Therefore, ED can be adopted to simplify and accelerate the fabrication process of an osteogenetic and antibacterial electrospun fibrous scaffold.
机译：由于其在骨科和其他相关领域的许多应用，Electromun纤维脚手架引起了许多研究兴趣。然而，聚合物支架体的有缺陷的表面活性显著限制了许多潜在的应用实施，有效解决仍然是研究人员一个很大的挑战。这里，提出了一种高效的方法，即具有共静电素纳米Ag掺杂剂的高效方法，即Puked电化学沉积（Ed），以制造聚（L-乳酸）/纳米-Ag复合纤维。所得产品显示出优异的抗菌性能，以及促进纤维表面磷酸钙晶体沉淀的强能力以及促进骨质发生分化。在ED的过程中，观察到纤维的电导率由于纳米Ag掺杂剂而增加。在充电时涂抹呕吐信号时，在阳极纤维的微反应区中发生水电解，形成OH-，允许磷酸钙过饱和的碱性环境。排出时，溶液中的磷酸钙快速扩散并降低浓度极化，重整均匀电解质。有效的生物活性涂层中的纤维表面的实现是通过重复上述的充电和放电过程中高度有效的方式来实现。因此，ED可以采用简化和加速成骨和抗菌静电纤维支架的制造工艺。

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  • 来源
    《RSC Advances》 |2018年第17期|共9页
  • 作者

    Wang Yingbo; Gao Ya; Xu Guoqiang; Liu Han; Xiang Yi; Cui Wenguo;

  • 作者单位

    Xinjiang Normal Univ Coll Chem Engn 102 Xinyi Rd Urumqi 830054 Peoples R China;

    Xinjiang Normal Univ Coll Chem Engn 102 Xinyi Rd Urumqi 830054 Peoples R China;

    Xinjiang Med Univ Affiliated Hosp 1 Dept Prosthodont 393 Xinyi Rd Urumqi 830054 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Key Lab Prevent &

    Treatment Bone &

    Joint Shanghai Inst Traumatol &

    Orthopaed Sch Med Rujin Hosp 197 Ruijin 2nd Rd Shanghai 200025 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Key Lab Prevent &

    Treatment Bone &

    Joint Shanghai Inst Traumatol &

    Orthopaed Sch Med Rujin Hosp 197 Ruijin 2nd Rd Shanghai 200025 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Key Lab Prevent &

    Treatment Bone &

    Joint Shanghai Inst Traumatol &

    Orthopaed Sch Med Rujin Hosp 197 Ruijin 2nd Rd Shanghai 200025 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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