...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Pharmacokinetics of chronically administered all-trans-retinoyl-β-glucuronide in mice
【24h】

Pharmacokinetics of chronically administered all-trans-retinoyl-β-glucuronide in mice

机译：长期服用全反式维甲酸-β-葡萄糖醛酸苷在小鼠体内的药代动力学

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

After the subcutaneous injection of retinoyl β-glucuronide (RAG), both RAG and retinoic acid (RA), formed by the hydrolysis of RAG in vivo, achieved peak plasma concentrations within 1-2 h. Thereafter, RA was rapidly cleared from the plasma whereas RAG was eliminated much more slowly. No significant changes were noted in the peak (2 h) plasma levels of RAG for treatment periods up to 56 days (one injection of RAG/day), in the clearance rate of RAG from plasma, or in plasma retinol. Similarly, no consistent decrease in plasma levels of the RA hydrolysis product was observed. Mice undergoing these long-term chronic treatments with RAG did not show any clinical manifestations of retinoid toxicity. Taken together, our findings that chronic dosing with RAG produces sustained levels of both the parent compound and the RA hydrolysis product, combined with the apparent low toxicity of RAG, suggest that RAG could be a safe and useful alternative to some retinoids which are presently being utilized in the clinic.
机译：皮下注射视黄酰基β-葡糖醛酸（RAG）后，RAG和RAG在体内水解形成的视黄酸（RA）均在1-2小时内达到峰值血浆浓度。此后，RA从血浆中快速清除，而RAG清除的速度要慢得多。在长达56天（一次注射RAG /天）的治疗期内，RAG的峰值（2小时）血浆水平，血浆中RAG的清除率或血浆视黄醇中均未见明显变化。类似地，未观察到RA水解产物的血浆水平一致降低。接受过RAG长期长期治疗的小鼠未显示类维生素A毒性的任何临床表现。综上，我们的发现表明，长期服用RAG可以持续产生母体化合物和RA水解产物的水平，再加上RAG明显的低毒性，这表明RAG可以替代目前使用的一些类维生素A，是一种安全且有用的替代品用于诊所。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号