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首页> 外文期刊>RSC Advances >Hybrid red blood cell membrane coated porous silicon nanoparticles functionalized with cancer antigen induce depletion of T cells
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Hybrid red blood cell membrane coated porous silicon nanoparticles functionalized with cancer antigen induce depletion of T cells

机译：用癌症抗原赋予杂交红细胞膜涂覆多孔硅纳米颗粒诱导T细胞的耗尽

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摘要

Erythrocyte-based drug delivery systems have been investigated for their biocompatibility, long circulation time, and capability to transport cargo all around the body, thus presenting enormous potential in medical applications. In this study, we investigated hybrid nanoparticles consisting of nano-sized autologous or allogeneic red blood cell (RBC) membranes encapsulating porous silicon nanoparticles (PSi NPs). These NPs were functionalized with a model cancer antigen TRP2, which was either expressed on the surface of the RBCs by a cell membrane-mimickingblockcopolymer polydimethylsiloxane-b-poly-2-methyl-2-oxazoline, or attached on the PSi NPs, thus hidden within the encapsulation. When in the presence of peripheral blood immune cells, these NPs resulted in apoptotic cell death of T cells, where the NPs having TRP2 within the encapsulation led to a stronger T cell deletion. The deletion of the T cells did not change the relative proportion of CD4(+)and cytotoxic CD8(+)T cells. Overall, this work shows the combination of nano-sized RBCs, PSi, and antigenic peptides may have use in the treatment of autoimmune diseases.
机译：已经研究了基于红细胞的药物递送系统，用于它们的生物相容性，长循环时间和能力，可以在身体周围运输货物，从而在医疗应用中呈现巨大潜力。在该研究中，我们研究了由包封多孔硅纳米颗粒（PSI NPS）的纳米尺寸的自体或同种异体红细胞（RBC）膜组成的杂化纳米颗粒。用模型癌抗原Trp2官能化，其通过细胞膜 - 模拟伯烷聚合物聚二甲基硅氧烷-B-甲基-2-恶唑啉在RBC的表面上表达，或者附着在PSI NP上，因此隐藏起来在封装内。当在存在外周血免疫细胞时，这些NPS导致T细胞的凋亡细胞死亡，其中在包封内的TRP2的NPS导致更强的T细胞缺失。 T细胞的缺失没有改变CD4（+）和细胞毒性CD8（+）T细胞的相对比例。总体而言，这项工作表明纳米大小的RBC，PSI和抗原肽的组合可用于治疗自身免疫疾病。

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  • 来源
    《RSC Advances》 |2020年第58期|共8页
  • 作者

    Rahikkala Antti; Fontana Flavia; Bauleth-Ramos Tomas; Correia Alexandra; Kemell Marianna; Seitsonen Jani; Makila Ermei; Sarmento Bruno; Salonen Jarno; Ruokolainen Janne; Hirvonen Jouni; Santos Helder A.;

  • 作者单位

    Univ Helsinki Fac Pharm Div Pharmaceut Chem &

    Technol Drug Res Program FI-00014 Helsinki Finland;

    Univ Helsinki Fac Pharm Div Pharmaceut Chem &

    Technol Drug Res Program FI-00014 Helsinki Finland;

    Univ Porto Inst Invest &

    Inovacao Saude I3S Rua Alfredo Allen 208 P-4200135 Porto Portugal;

    Univ Helsinki Fac Pharm Div Pharmaceut Chem &

    Technol Drug Res Program FI-00014 Helsinki Finland;

    Univ Helsinki Dept Chem FI-00014 Helsinki Finland;

    Aalto Univ Nanomicroscopy Ctr FI-02150 Espoo Finland;

    Univ Turku Dept Phys Lab Ind Phys FI-20014 Turku Finland;

    Inst Univ Ciencias Saude Inst Invest &

    Formacao Avancada Ciencias &

    Tecnol CESPU P-4585116 Gandra Portugal;

    Univ Turku Dept Phys Lab Ind Phys FI-20014 Turku Finland;

    Aalto Univ Nanomicroscopy Ctr FI-02150 Espoo Finland;

    Univ Helsinki Fac Pharm Div Pharmaceut Chem &

    Technol Drug Res Program FI-00014 Helsinki Finland;

    Univ Helsinki Fac Pharm Div Pharmaceut Chem &

    Technol Drug Res Program FI-00014 Helsinki Finland;

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