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首页> 外文期刊>RSC Advances >Curcumin loaded zinc oxide nanoparticles for activity-enhanced antibacterial and anticancer applications
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Curcumin loaded zinc oxide nanoparticles for activity-enhanced antibacterial and anticancer applications

机译：用于活性增强的抗菌和抗癌应用的姜黄素负载氧化锌纳米颗粒

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Zinc oxide nanoparticles and curcumin have been shown to be excellent antimicrobial agents and promising anticancer agents, both on their own as well as in combination. Together, they have potential as alternatives/supplements to antibiotics and traditional anticancer drugs. In this study, different morphologies of zinc oxide-grafted curcumin nanocomposites (ZNP-Cs) were synthesized and characterized using SEM, TGA, FTIR, XRD and UV-vis spectrophotometry. Antimicrobial assays were conducted against both Gram negative and Gram-positive bacterial stains. Spherical ZnO-curcumin nanoparticles (SZNP-Cs) and rod-shaped ZnO-curcumin nanoparticles showed the most promising activity against tested bacterial strains. The inhibition zones for these curcumin-loaded ZnO nanocomposites were consistently larger than their bare counterparts or pure curcumin, revealing an additve effect between the ZnO and curcumin components. The potential anticancer activity of the synthesized nanocomposites was studied on the rhabdomyosarcoma RD cell lineviaMTT assay, while their cytotoxic effects were tested against human embryonic kidney cells using the resazurin assay. SZNP-Cs exhibited the best balance between the two, showing the lowest toxicity against healthy cells and good anticancer activity. The results of this investigation demonstrate that the nanomatrix synthesized can act as an effective, additively-enhanced combination delivery/therapeutic agent, holding promise for anticancer therapy and other biomedical applications.
机译：氧化锌纳米颗粒和姜黄素已被证明是优异的抗微生物剂和有前途的抗癌剂，两者都是自身的以及组合。它们一起具有抗生素和传统抗癌药物的替代品/补充剂。在该研究中，使用SEM，TGA，FTIR，XRD和UV-Vis分光光度法合成并表征了氧化锌接枝姜黄素纳米复合材料（ZnP-CS）的不同形态。针对革兰氏阴性和革兰氏阳性细菌污渍进行抗微生物测定。球形ZnO-姜黄素纳米颗粒（SZNP-CS）和棒状ZnO-姜黄素纳米颗粒显示出对测试细菌菌株最有前途的活性。这些姜黄素负载的ZnO纳米复合材料的抑制区始终大于其裸对应物或纯姜黄素，揭示ZnO和姜黄素组分之间的含量凋亡。研究了合成纳米复合材料的潜在抗癌活性在横纹肌肉瘤RD细胞系中进行，同时使用转基因测定法对人胚胎肾细胞进行细胞毒性作用。 SZNP-CS在两者之间表现出最佳平衡，显示出对健康细胞和良好抗癌活动的最低毒性。该研究的结果表明，纳米立方rix可以作为有效，增强增强的组合递送/治疗剂，持有抗癌治疗和其他生物医学应用。

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  • 来源
    《RSC Advances》 |2020年第51期|共11页
  • 作者

    Perera W. P. T. D.; Dissanayake Ranga K.; Ranatunga U. I; Hettiarachchi N. M.; Perera K. D. C.; Unagolla Janitha M.; De Silva R. T.; Pahalagedara L. R.;

  • 作者单位

    Acad Sri Lanka Inst Nanotechnol Nanotechnol &

    Sci Pk Pitipana 10206 Homagama Sri Lanka;

    Sri Lanka Inst Nanotechnol Nanotechnol &

    Sci Pk Pitipana 10206 Homagama Sri Lanka;

    Univ Colombo Fac Med Dept Biochem &

    Mol Biol 25 Kynsey Rd Colombo 00800 Sri Lanka;

    Acad Sri Lanka Inst Nanotechnol Nanotechnol &

    Sci Pk Pitipana 10206 Homagama Sri Lanka;

    Acad Sri Lanka Inst Nanotechnol Nanotechnol &

    Sci Pk Pitipana 10206 Homagama Sri Lanka;

    Univ Toledo Coll Engn Dept Bioengn Biomed Engn Program Toledo OH 43607 USA;

    Sri Lanka Inst Nanotechnol Nanotechnol &

    Sci Pk Pitipana 10206 Homagama Sri Lanka;

    Sri Lanka Inst Nanotechnol Nanotechnol &

    Sci Pk Pitipana 10206 Homagama Sri Lanka;

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