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首页> 外文期刊>RSC Advances >PEGylated gold nanorods with a broad absorption band in the first near-infrared window for in vivo multifunctional photoacoustic imaging
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PEGylated gold nanorods with a broad absorption band in the first near-infrared window for in vivo multifunctional photoacoustic imaging

机译：在第一个近红外窗口中具有宽吸收带的聚乙二醇化金纳米棒用于体内多功能光声成像

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摘要

Nanoparticles with absorbances in the near-infrared window (NIR, 700-1300 nm) are ideal contrast agents for in vivo imaging of deep tissue with high signal-to-noise ratios. By using CTAB and l(+)-ascorbic acid (AA) as ligands to effectively balance particle nucleation and growth, PEGylated Au nanorods (NRs) with broad absorption bands (from 650 to 1100 nm) in the first NIR window could be successfully realized. The morphologies, crystal structures, absorption and biotoxicities of the samples were determined by TEM, TGA, UV-vis and MTT assay. The results indicated that the presence of a thin poly(ethylene glycol) (PEG) shell could greatly improve the biocompatibility of the Au NRs (1.7 times that of non-PEGylated Au NRs), making them harmless to living cells. Moreover, the prepared PEGylated Au NRs displayed the highest image contrast and SNR values (1.1-1.5 times that of commercial Au nanospheres and NRs), with excitation lasers of 532, 680 and 828 nm, showing their great potential for use in multicolor photoacoustic imaging in vivo. With the prepared PEGylated Au NRs, a functional image of oxygen saturation was constructed in a single step without changing the contrast agent.
机译：具有近红外窗口（NIR，700-1300nm）中吸光度的纳米颗粒是具有高信噪比的深组织的体内成像的理想造影剂。通过使用CTAB和L（+） - 抗坏血酸（AA）作为配体，以有效地平衡颗粒成核和生长，可以成功实现第一NIR窗口中具有宽吸收带（从650至1100nm）的聚乙二醇化Au纳米棒（NRS） 。通过TEM，TGA，UV-VI和MTT测定法测定样品的形态，晶体结构，吸收和生物毒性。结果表明，薄的聚（乙二醇）（PEG）壳的存在可以大大改善Au NRS的生物相容性（非聚乙二醇化的Au NRS的1.7倍），使它们对活细胞无害。此外，制备的聚乙二醇化的AU NRS显示出最高的图像对比度和SNR值（商业AU纳米球和NRS的1.1-1.5倍），激发激光激光为532,680和828nm，显示它们在多色光声成像中使用的巨大潜力体内。利用制备的聚乙二醇化的Au NRS，在单一步骤中构建氧饱和的功能图像而不改变造影剂。

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  • 来源
    《RSC Advances》 |2020年第8期|共7页
  • 作者

    Wang Yiping; Wu Yiduo; Wen Qiang; Li Pengwei; Wang Ying; Jiang Huabei; Zhang Wendong;

  • 作者单位

    Taiyuan Univ Technol Coll Informat &

    Comp Micronano Syst Res Ctr Taiyuan 030024 Shanxi Peoples R China;

    Taiyuan Univ Technol Coll Informat &

    Comp Micronano Syst Res Ctr Taiyuan 030024 Shanxi Peoples R China;

    Taiyuan Univ Technol Coll Informat &

    Comp Micronano Syst Res Ctr Taiyuan 030024 Shanxi Peoples R China;

    Taiyuan Univ Technol Coll Informat &

    Comp Micronano Syst Res Ctr Taiyuan 030024 Shanxi Peoples R China;

    Taiyuan Univ Technol Coll Mech Taiyuan 030024 Shanxi Peoples R China;

    Univ S Florida Dept Med Engn Biomed Opt Lab Coll Engn Tampa FL 33620 USA;

    Taiyuan Univ Technol Coll Informat &

    Comp Micronano Syst Res Ctr Taiyuan 030024 Shanxi Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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