Recent advances in the development of histone deacylase SIRT2 inhibitors

Yang Wenyu; Chen Wei; Su Huilin; Li Rong; Song Chen; Wang Zhouyu; Yang Lingling

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Recent advances in the development of histone deacylase SIRT2 inhibitors

机译：组蛋白脱酰基酶SIRT2抑制剂的开发的最新进展

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Sirtuin 2 (SIRT2) is an important and special member of the atypical histone deacetylase Sirtuin (SIRT) family. Due to its extensive catalytic effects, SIRT2 can regulate autophagy, myelination, immunity, inflammation and other physiological processes. Recent evidence revealed that dysregulation of human SIRT2 activity is associated with the pathogenesis and prognosis of cancers, Parkinson's disease and other disorders; thus SIRT2 is a promising target for potential therapeutic intervention. This review presents a systematic summary of nine chemotypes of small-molecule SIRT2 inhibitors, particularly including the discovery and structural optimization strategies, which will be useful for future efforts to develop new inhibitors targeting SIRT2 and associated target proteins.

机译：Sirtuin 2（Sirt2）是非典型组蛋白脱乙酰酶Sirtuin（Sirt）家族的重要和特殊成员。由于其广泛的催化作用，SIRT2可以调节自噬，髓鞘，免疫，炎症和其他生理过程。最近的证据表明，人体SIRT2活性的失调与癌症，帕金森病等疾病的发病机制和预后有关; 因此，Sirt2是潜在治疗介入的有希望的目标。本综述介绍了九分型SIRT2抑制剂的九个趋化型，特别是包括发现和结构优化策略，这对于未来的努力开发靶向SIRT2和相关靶蛋白的新抑制剂是有用的。

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《RSC Advances》 |2020年第61期|共9页
作者
Yang Wenyu; Chen Wei; Su Huilin; Li Rong; Song Chen; Wang Zhouyu; Yang Lingling;
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作者单位

Xihua Univ Coll Food &

Bioengn Chengdu 610039 Peoples R China;

Xihua Univ Coll Food &

Bioengn Chengdu 610039 Peoples R China;

Xihua Univ Coll Food &

Bioengn Chengdu 610039 Peoples R China;

Xihua Univ Coll Food &

Bioengn Chengdu 610039 Peoples R China;

Xihua Univ Coll Food &

Bioengn Chengdu 610039 Peoples R China;

Xihua Univ Coll Sci Chengdu 610039 Sichuan Peoples R China;

Xihua Univ Coll Food &

Bioengn Chengdu 610039 Peoples R China;

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正文语种 eng
中图分类化学;
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1. Recent advances in the development of histone deacylase SIRT2 inhibitors [J] . Yang Wenyu, Chen Wei, Su Huilin, RSC Advances . 2020,第61期

机译：组蛋白脱酰基酶SIRT2抑制剂的开发的最新进展
2. Advances in the development of histone lysine demethylase inhibitors [J] . Maes Tamara, Carceller Elena, Salas Jordi, Current opinion in pharmacology . 2015,第Null期

机译：组蛋白赖氨酸脱甲基酶抑制剂的研究进展
3. Recent advances in small-molecule modulation of epigenetic targets: Discovery and development of histone methyltransferase and bromodomain inhibitors [J] . SweisR.F., MichaelidesM.R. Annual reports in medicinal chemistry. . 2013,第Null期

机译：表观遗传学目标的小分子调节的最新进展：组蛋白甲基转移酶和溴结构域抑制剂的发现和发展
4. Histone Deacetylase Inhibitor Corrects Historte H3K9 Modification in Round Spermatid DNA at the 2-Cell Stage and Increases ; the Development of ROSI Embryos . [C] . NT. Minh, N.B. Tu, N.T.T. Tram International Conference on the Development of Biomedical Engineering in Vietnam . 2018

机译：组蛋白脱乙酰酶抑制剂在2细胞阶段的圆形精子DNA中校正综合体H3K9改性并增加;罗西胚胎的发展。
5. The Synthetic Oleanane Triterpenoids and the Histone Deacetylase Inhibitor Vorinostat Cooperate to Delay Tumor Development in a Transgenic Model of Estrogen Receptor -- Negative Breast Cancer. [D] . Tran, Kim M. 2012

机译：合成的齐墩果烷三萜类化合物和组蛋白脱乙酰基酶抑制剂伏立诺他合用以延迟雌激素受体-阴性乳腺癌转基因模型中的肿瘤发展。
6. Development and Characterization of 3-(Benzylsulfonamido)benzamides as Potent and Selective SIRT2 Inhibitors [O] . Mohammad A. Khanfar, Luisa Quinti, Hua Wang, -1

机译：作为有效和选择性SIRT2抑制剂的3-（苄基磺酰胺基）苯甲酰胺的开发与表征
7. Recent advances in the development of histone deacylase SIRT2 inhibitors [O] . Wenyu Yang, Wei Chen, Huilin Su, 2020

机译：组蛋白脱酰基酶SIRT2抑制剂的开发的最新进展

Recent advances in the development of histone deacylase SIRT2 inhibitors

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