The purification and identification of immunoregulatory peptides from oyster (Crassostrea hongkongensis) enzymatic hydrolysate

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The purification and identification of immunoregulatory peptides from oyster (Crassostrea hongkongensis) enzymatic hydrolysate

机译：来自牡蛎（Crassostra'Hongkongensis）酶水解产物的免疫调节肽的纯化和鉴定

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Oysters, favored as a delicious seafood by people worldwide, contain various nutritional components, especially proteins. In this work, the immunoregulatory peptides were isolated and purified from oyster enzymatic hydrolysate by utilizing anion exchange chromatography and RP-HPLC, and were identified via LC-MS/MS. A proliferation assay, a phagocytosis assay, and TNF-alpha production, NO production and IL-6 production assays were used to examine the immunoregulatory effects of the two identified peptides. The results indicate that the peptides, DNSIAMESMK (P1) and LLQLGSGR (P2), increased the proliferation rate of macrophages, TNF-alpha and NO production, IL-6 production, and the phagocytosis ability, but to different degrees; P2, with more hydrophobic amino acids, was more potent than P1. This suggested that these peptides might be potential candidates for developing immunoregulatory functional foods and nutraceuticals.

机译：牡蛎作为全球人士作为美味的海鲜，含有各种营养成分，尤其是蛋白质。在这项工作中，通过利用阴离子交换色谱和RP-HPLC分离和纯化免疫抑制肽，并通过LC-MS / MS鉴定。增殖测定，吞噬作用测定和TNF-α产生，没有生产和IL-6产生测定来检查两个鉴定的肽的免疫造环作用。结果表明，肽，DNSIAMESMK（P1）和LLQLGSGR（P2）增加了巨噬细胞，TNF-α和NO生产的增殖率，IL-6生产和吞噬作用，但不同程度; P2，具有更多疏水性氨基酸，比P1更有效。这表明这些肽可能是开发免疫调节功能性食品和营养保健品的潜在候选者。

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《RSC Advances》 |2019年第56期|共10页
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1. The purification and identification of immunoregulatory peptides from oyster (Crassostrea hongkongensis) enzymatic hydrolysate [J] . RSC Advances . 2019,第56期

机译：来自牡蛎（Crassostra'Hongkongensis）酶水解产物的免疫调节肽的纯化和鉴定
2. Purification and identification of intestinal mucosal cell proliferation-promoting peptides from Crassostrea hongkongensis [J] . Pan Jianyu, Wan Peng, Chen Deke, European food research and technology =: Zeitschrift fur Lebensmittel-Untersuchung und -Forschung. A . 2019,第3期

机译：来自克隆康康的肠粘膜细胞增殖促进肽的纯化和鉴定
3. Purification and identification of a ACE inhibitory peptide from oyster proteins hydrolysate and the antihypertensive effect of hydrolysate in spontaneously hypertensive rats [J] . Jiapei Wang, Jianen Hu, Jinzhe Cui, Food Chemistry . 2008,第2期

机译：自发性高血压大鼠牡蛎蛋白水解产物中ACE抑制肽的纯化，鉴定及水解产物的降压作用
4. ACE inhibitory peptides derived from sarcoplasmic enzymatic hydrolysate of freshwater fish haruan [C] . Ghassem M., Babji A.S., Said M. ICoMST 2011;International conference of meat science and technology . 2012

机译：淡水鱼haruan的胞质酶解产物ACE抑制肽。
5. Purification, biochemistry and expression of metallothionein isoforms in the American oyster, Crassostrea virginica [D] . DiNovo, Augustine Anthony. 2001

机译：美国牡蛎Crassostrea virginica中金属硫蛋白同工型的纯化，生物化学和表达
6. Ameliorative Effects of Peptides from the Oyster (Crassostrea hongkongensis) Protein Hydrolysates against UVB-Induced Skin Photodamage in Mice [O] . Zhilan Peng, Beibei Chen, Qinsheng Zheng, 2020

机译：牡蛎（Crassostrea hongkongensis）蛋白水解物肽对UVB诱导的小鼠皮肤光损伤的改善作用
7. The purification and identification of immunoregulatory peptides from oyster (Crassostrea hongkongensis) enzymatic hydrolysate [O] . Wan Li, Cheng Xu, Chaohua Zhang, 2019

机译：来自牡蛎（Crassostra'Hongkongensis）酶水解产物的免疫调节肽的纯化和鉴定

The purification and identification of immunoregulatory peptides from oyster (Crassostrea hongkongensis) enzymatic hydrolysate

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