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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Neonatal Abstinence Syndrome and Associated Neonatal and Maternal Mortality and Morbidity
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Neonatal Abstinence Syndrome and Associated Neonatal and Maternal Mortality and Morbidity

机译：新生儿禁欲综合征和相关新生儿和孕产妇死亡率和发病率

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OBJECTIVES: We examined demographic characteristics and birth outcomes of infants with neonatal abstinence syndrome (NAS) and their mothers in Canada. METHODS: This retrospective, population-based, descriptive cross-sectional study of mother-infant dyads included all singleton live births in Canada (excluding Quebec), from 2005-2006 to 2015-2016 (N = 2 881 789). Demographic characteristics, NAS, and neonatal and maternal morbidities were identified from delivery hospitalization data (including diagnostic codes). The main composite outcomes were maternal and neonatal mortality and/or severe morbidity, including death and potentially life-threatening conditions in the mother and the infant, respectively. Logistic regression yielded adjusted odds ratios (aORs) and 95% confidence intervals (CIs). RESULTS: The study included 10 027 mother-infant dyads with NAS. The incidence of NAS increased from 0.20% to 0.51%. Maternal mortality was 1.99 vs 0.31 per 10 000 women in the NAS group versus the comparison group (aOR = 6.53; 95% CI: 1.59 to 26.74), and maternal mortality and/or severe morbidity rates were 3.10% vs 1.35% (aOR = 2.21; 95% CI: 1.97 to 2.49). Neonatal mortality was 0.12% vs 0.19% (aOR = 0.28; 95% CI: 0.15 to 0.53), and neonatal mortality and/or severe morbidity rates were 6.36% vs 1.73% (aOR = 2.27; 95% CI: 2.06 to 2.50) among infants with NAS versus without NAS. CONCLUSIONS: NAS incidence increased notably in Canada between 2005-2006 and 2015-2016. Infants with NAS had elevated severe morbidity, and their mothers had elevated mortality and severe morbidity. These results highlight the importance of implementing integrated care services to support the mother-infant dyad during childbirth and in the postpartum period.
机译：目的：我们在加拿大审查了新生儿禁忌综合征（NAS）及其母亲的人口统计特征和出生结果。方法：这种回顾性，基于人口的母婴二元的描述性横截面研究包括加拿大（不包括魁北克省）的所有单例居住，2005 - 2006年至2015-2016（n = 2 881 789）。从递送住院数据（包括诊断代码）鉴定了人口特征，NAS和新生儿和母体病理。主要复合结果是母亲和新生儿死亡率和/或严重的发病率，包括母亲和婴儿的死亡和潜在的危及生命情况。逻辑回归产生调整的差距（AOR）和95％置信区间（CIS）。结果：该研究包括1027个母婴与NAS的母婴。 NAS的发病率从0.20％增加到0.51％。 NAS组中每10 000名妇女的孕产妇死亡率为每10 000名妇女与比较组（AOR = 6.53; 95％CI：1.59至26.74），孕产妇死亡率和/或严重的发病率为3.10％VS 1.35％（AOR = 2.21; 95％CI：1.97至2.49）。新生儿死亡率为0.12％Vs 0.19％（AOR = 0.28; 95％CI：0.15至0.53），新生儿死亡率和/或严重发病率为6.36％Vs 1.73％（AOR = 2.27; 95％CI：2.06至2.50）在没有NAS的NAS与NAS的婴儿中。结论：2005-2006和2015-2016之间的加拿大NAS发病率显着增加。患有NAS的婴儿发病率升高，他们的母亲患有了死亡率升高和严重的发病率。这些结果突出了实施综合护理服务的重要性，以便在分娩期间和产后期间支持母婴二对。

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