...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physics in medicine and biology. >Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study
【24h】

Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study

机译：使用DCE-MRI评估转红霉肿瘤水交换分析对治疗响应评估的影响：比较研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study compares the shutter-speed (SS) and the Tofts models as used in assessing therapeutic response in a longitudinal DCE-MRI experiment. Sixteen nu/nu mice with implanted colorectal adenocarcinoma cell line (LS-174T) were randomly assigned into treatment/control groups (n = 8/group) and received bevacizumab/saline twice weekly (Day1/Day4/Day8). All mice were scanned at one pre-(Day0) and two post-treatment (Day2/Day9) time points using a high spatiotemporal resolution DCE-MRI pulse sequence. The CA extravasation rate constant K-T(trans)/K-S(trans) from the Tofts/SS model and the mean intracellular water residence time tau(i) from the SS model were analyzed. A biological subvolume (BV) within the tumor was identified based on the tau(i) intensity distribution, and the SS model parameters within the BV (K-S,BV(trans) and tau(i,BV)) were analyzed. It is found that K-S(trans) and K-T(trans) have a similar spatial distribution in the tumor volume. The Bayesian information criterion results show that the SS model was a better fit for all scans. At Day9, the treatment group had significantly higher tumor mean K-T(trans) (p = 0.021), K-S(trans) (p = 0.021) and tau(i) (p = 0.045). When BV from transcytolemmal water exchange analysis was adopted, the treatment group had higher mean K-S,BV(trans) at both Day2 (p = 0.038) and Day9 (p = 0.007). Additionally, at Day9, the treatment group had higher mean tau(i,BV) (p = 0.045) and higher K-S,BV(trans) spatial heterogeneity indices (Renyi dimensions) d(1) (p = 0.010) and d(2) (p = 0.021). When mean K-S,K-BV (trans) and its coefficient of variation (CV) were used to separate treatment/control group samples using supporting vector machine, the accuracy of treatment/control classification was 68.8% at Day2 and 87.5% at Day9; in contrast, the Day2/Day9 accuracy were 62.5%/87.5% using tumor mean K-S(trans) and its CV and were 50.0%/87.5% using tumor mean K-T(trans) and its CV, respectively. These results suggest that the SS model parameters outperformed the Tofts model parameters in terms of capturing bevacizumab therapeutic effect in this longitudinal experiment.
机译：本研究比较了在纵向DCE-MRI实验中评估治疗响应的快门速度（SS）和TOFTS模型。将植入结肠直肠腺癌细胞系（LS-174T）随机分配到治疗/对照组（n = 8 /组）中，并在每周两次（第1天/天/天）进行贝伐单抗/盐水。使用高时的时态分辨率DCE-MRI脉冲序列，在预（Day0）和两次后处理（Day2 / Day9）时间点处扫描所有小鼠。分析了来自TOFTS / SS模型的CA外向速率常数K-T（Trans）/ K-S（Trans）以及来自SS模型的平均细胞内水停留时间Tau（I）。基于TAU（I）强度分布鉴定肿瘤内的生物亚荚膜（BV），分析了BV（K-S，BV（Trans）和Tau（I，BV）内的SS模型参数。发现K-S（反式）和K-T（Trans）在肿瘤体积中具有类似的空间分布。贝叶斯信息标准结果表明，SS模型更适合所有扫描。在第9天，治疗组具有显着更高的肿瘤平均值K-T（Trans）（P = 0.021），K-S（Trans）（P = 0.021）和Tau（I）（p = 0.045）。当采用转红霉醛水交换分析时，治疗组在Day2（P = 0.038）和Day9（P = 0.007）中具有更高的平均K-S，BV（Trans）。另外，在第9天，治疗组平均值（I，BV）（P = 0.045）和更高的Ks，BV（Trans）空间异质性指数（renyi尺寸）D（1）（P = 0.010）和D（2 ）（p = 0.021）。当平均值K-S，K-BV（Trans）及其变异系数（CV）使用支撑载体机来分离治疗/对照组样品时，治疗/对照分类的准确性在Day2和Day9日期为68.8％;相比之下，使用肿瘤平均值K-S（Trans）及其CV的Day2 / Day9精度为62.5％/ 87.5％，并且使用肿瘤平均K-T（Trans）及其CV分别为50.0％/ 87.5％。这些结果表明SS模型参数在捕获该纵向实验中捕获Bevacizumab治疗效果方面优于Tofts模型参数。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号