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首页> 外文期刊>Physics in medicine and biology. >Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study
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Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study

机译：使用DCE-MRI评价跨细胞膜水交换分析对治疗反应评估的效果：一项比较研究

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This study compares the shutter-speed (SS) and the Tofts models as used in assessing therapeutic response in a longitudinal DCE-MRI experiment. Sixteen nuu mice with implanted colorectal adenocarcinoma cell line (LS-174T) were randomly assigned into treatment/control groups (n = 8/group) and received bevacizumab/saline twice weekly (Day1/Day4/Day8). All mice were scanned at one pre-(Day0) and two post-treatment (Day2/Day9) time points using a high spatiotemporal resolution DCE-MRI pulse sequence. The CA extravasation rate constant K-T(trans)/K-S(trans) from the Tofts/SS model and the mean intracellular water residence time tau(i) from the SS model were analyzed. A biological subvolume (BV) within the tumor was identified based on the tau(i) intensity distribution, and the SS model parameters within the BV (K-S,BV(trans) and tau(i,BV)) were analyzed. It is found that K-S(trans) and K-T(trans) have a similar spatial distribution in the tumor volume. The Bayesian information criterion results show that the SS model was a better fit for all scans. At Day9, the treatment group had significantly higher tumor mean K-T(trans) (p = 0.021), K-S(trans) (p = 0.021) and tau(i) (p = 0.045). When BV from transcytolemmal water exchange analysis was adopted, the treatment group had higher mean K-S,BV(trans) at both Day2 (p = 0.038) and Day9 (p = 0.007). Additionally, at Day9, the treatment group had higher mean tau(i,BV) (p = 0.045) and higher K-S,BV(trans) spatial heterogeneity indices (Renyi dimensions) d(1) (p = 0.010) and d(2) (p = 0.021). When mean K-S,K-BV (trans) and its coefficient of variation (CV) were used to separate treatment/control group samples using supporting vector machine, the accuracy of treatment/control classification was 68.8% at Day2 and 87.5% at Day9; in contrast, the Day2/Day9 accuracy were 62.5%/87.5% using tumor mean K-S(trans) and its CV and were 50.0%/87.5% using tumor mean K-T(trans) and its CV, respectively. These results suggest that the SS model parameters outperformed the Tofts model parameters in terms of capturing bevacizumab therapeutic effect in this longitudinal experiment.
机译：这项研究比较了纵向DCE-MRI实验中用于评估治疗反应的快门速度（SS）和Tofts模型。将十六只nu / nu小鼠植入大肠腺癌细胞系（LS-174T）随机分为治疗/对照组（n = 8 /组），并每周两次（第1天/第4天/第8天）接受贝伐单抗/盐水。使用高时空分辨率DCE-MRI脉冲序列在一个治疗前（第0天）和治疗后两个（第2天/第9天）时间点扫描所有小鼠。分析了来自Tofts / SS模型的CA外渗速率常数K-T（trans）/ K-S（trans）和来自SS模型的平均细胞内水停留时间tau（i）。根据tau（i）强度分布确定肿瘤内的生物子体积（BV），并分析BV内的SS模型参数（K-S，BV（trans）和tau（i，BV））。发现K-S（反式）和K-T（反式）在肿瘤体积中具有相似的空间分布。贝叶斯信息准则结果表明，SS模型更适合所有扫描。在第9天，治疗组的肿瘤平均K-T（反式）（p = 0.021），K-S（反式）（p = 0.021）和tau（i）（p = 0.045）显着更高。当采用通过跨细胞膜水交换分析的BV时，治疗组在第2天（p = 0.038）和第9天（p = 0.007）的平均K-S，BV（trans）均较高。此外，在第9天，治疗组的平均tau（i，BV）（p = 0.045）和KS，BV（trans）空间异质性指数（Renyi维度）分别为d（1）（p = 0.010）和d（2） ）（p = 0.021）。当使用支持向量机将平均K-S，K-BV（反式）及其变异系数（CV）用于分离治疗/对照组样本时，治疗/对照分类的准确性在第2天为68.8％，在第9天为87.5％;相比之下，使用肿瘤平均K-S（trans）及其CV，Day2 / Day9的准确度分别为62.5％/ 87.5％和使用肿瘤平均K-T（trans）及其CV分别为50.0％/ 87.5％。这些结果表明，在该纵向实验中，在捕获贝伐单抗的治疗效果方面，SS模型参数优于Tofts模型参数。

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