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首页> 外文期刊>Physics in medicine and biology. >Monte Carlo verification of polymer gel dosimetry applied to radionuclide therapy: a phantom study.
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Monte Carlo verification of polymer gel dosimetry applied to radionuclide therapy: a phantom study.

机译：Monte Carlo验证聚合物凝胶剂量测定验证，适用于放射性核素治疗：幻影研究。

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This study evaluates the dosimetric performance of the polymer gel dosimeter 'Methacrylic and Ascorbic acid in Gelatin, initiated by Copper' and its suitability for quality assurance and analysis of I-131-targeted radionuclide therapy dosimetry. Four batches of gel were manufactured in-house and sets of calibration vials and phantoms were created containing different concentrations of I-131-doped gel. Multiple dose measurements were made up to 700 h post preparation and compared to equivalent Monte Carlo simulations. In addition to uniformly filled phantoms the cross-dose distribution from a hot insert to a surrounding phantom was measured. In this example comparisons were made with both Monte Carlo and a clinical scintigraphic dosimetry method. Dose-response curves generated from the calibration data followed a sigmoid function. The gels appeared to be stable over many weeks of internal irradiation with a delay in gel response observed at 29 h post preparation. This was attributed to chemical inhibitors and slow reaction rates of long-chain radical species. For this reason, phantom measurements were only made after 190 h of irradiation. For uniformly filled phantoms of I-131 the accuracy of dose measurements agreed to within 10% when compared to Monte Carlo simulations. A radial cross-dose distribution measured using the gel dosimeter compared well to that calculated with Monte Carlo. Small inhomogeneities were observed in the dosimeter attributed to non-uniform mixing of monomer during preparation. However, they were not detrimental to this study where the quantitative accuracy and spatial resolution of polymer gel dosimetry were far superior to that calculated using scintigraphy. The difference between Monte Carlo and gel measurements was of the order of a few cGy, whilst with the scintigraphic method differences of up to 8 Gy were observed. A manipulation technique is also presented which allows 3D scintigraphic dosimetry measurements to be compared to polymer gel dosimetry measurements without generating misleading errors due to the limited spatial resolution.
机译：本研究评估了聚合物凝胶的剂量计“甲基丙烯酸类和抗坏血酸在明胶，由铜发起”及其对I-131靶向放射性核素治疗剂量的质量保证和分析适宜的剂量测定性能。凝胶的四批内部制造和创建组校准小瓶和体模的含有不同浓度的I-131-掺杂凝胶。多剂量进行了测量高达700小时后制备并与等效Monte Carlo模拟。除了均匀地填充体模测量从热插件横剂量分布到周围幻象。在此实例中的比较用两者蒙特卡洛和临床闪烁照相剂量测定方法进行说明。从校准数据产生剂量反应曲线遵循S形函数。凝胶似乎是在许多周的内部照射的稳定与在29小时后观察到的制备凝胶响应延迟。这是由于化学抑制剂和长链自由基的反应速率慢。出于这个原因，幻测量仅照射190个小时后制成。对于I-131均匀地填充模体剂量测量的精确度相比，Monte Carlo模拟当在10％以内的同意。使用比较好于与蒙特卡罗计算的凝胶剂量计的径向横剂量分布测量。在制备过程中归因于单体的非均匀混合的剂量计观察到小的不均匀性。然而，他们不损害本研究，其中定量的准确性和聚合物凝胶剂量的空间分辨率远优于使用显像计算。蒙特卡洛和凝胶测量值之间的差为几cGy的数量级的，而与观察到高达8 Gy的闪烁照相方法的差异。还提出了一种操纵技术，它允许3D闪烁照相剂量测量进行比较，以聚合物凝胶剂量测量，而不产生误差误导由于有限的空间分辨率。

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