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首页> 外文期刊>Physics in medicine and biology. >Monte Carlo verification of polymer gel dosimetry applied to radionuclide therapy: a phantom study.
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Monte Carlo verification of polymer gel dosimetry applied to radionuclide therapy: a phantom study.

机译：Monte Carlo验证聚合物凝胶剂量测定验证，适用于放射性核素治疗：幻影研究。

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This study evaluates the dosimetric performance of the polymer gel dosimeter 'Methacrylic and Ascorbic acid in Gelatin, initiated by Copper' and its suitability for quality assurance and analysis of I-131-targeted radionuclide therapy dosimetry. Four batches of gel were manufactured in-house and sets of calibration vials and phantoms were created containing different concentrations of I-131-doped gel. Multiple dose measurements were made up to 700 h post preparation and compared to equivalent Monte Carlo simulations. In addition to uniformly filled phantoms the cross-dose distribution from a hot insert to a surrounding phantom was measured. In this example comparisons were made with both Monte Carlo and a clinical scintigraphic dosimetry method. Dose-response curves generated from the calibration data followed a sigmoid function. The gels appeared to be stable over many weeks of internal irradiation with a delay in gel response observed at 29 h post preparation. This was attributed to chemical inhibitors and slow reaction rates of long-chain radical species. For this reason, phantom measurements were only made after 190 h of irradiation. For uniformly filled phantoms of I-131 the accuracy of dose measurements agreed to within 10% when compared to Monte Carlo simulations. A radial cross-dose distribution measured using the gel dosimeter compared well to that calculated with Monte Carlo. Small inhomogeneities were observed in the dosimeter attributed to non-uniform mixing of monomer during preparation. However, they were not detrimental to this study where the quantitative accuracy and spatial resolution of polymer gel dosimetry were far superior to that calculated using scintigraphy. The difference between Monte Carlo and gel measurements was of the order of a few cGy, whilst with the scintigraphic method differences of up to 8 Gy were observed. A manipulation technique is also presented which allows 3D scintigraphic dosimetry measurements to be compared to polymer gel dosimetry measurements without generating misleading errors due to the limited spatial resolution.
机译：该研究评估了聚合物凝胶剂量计的甲基丙烯酸和抗坏血酸在明胶中的抗坏血酸的剂量测定，并通过铜引发的适用性和I-131靶辐射核素治疗剂量测定剂的质量保证和分析。在内部制造四批凝胶，并产生含有不同浓度的I-131-掺杂凝胶的校准小瓶和幽灵组。多剂量测量后，制备高达700小时，并与同等的蒙特卡罗模拟相比。除了均匀填充的Phantoms之外，测量从热插入物到周围体模的交叉剂量分布。在该示例中，使用蒙特卡罗和临床闪烁的剂量测定方法进行比较。从校准数据生成的剂量 - 响应曲线遵循SIGMOID函数。凝胶在多周的内部照射中似乎是稳定的，在29小时后观察到凝胶反应的延迟。这归因于化学抑制剂和长链自由基物质的缓慢反应速率。因此，仅在190小时的辐射后进行幻影测量。对于I-131的均匀填充幽灵，与蒙特卡罗模拟相比，剂量测量的准确性同意10％。使用凝胶剂量计测量的径向交叉剂量分布与Monte Carlo计算的孔相比。在制剂期间归因于单体的不均匀混合的剂量计中观察到小的不均匀性。然而，它们对该研究并不有害，其中聚合物凝胶剂量法的定量准确度和空间分辨率远远优于使用闪烁图计算的。蒙特卡洛和凝胶测量之间的差异是几个CGY的顺序，而透明度方法观察到最多8 Gy的差异。还提出了一种操纵技术，其允许3D闪烁的剂量测量测量与聚合物凝胶剂量测定测量进行比较，而不会由于限制空间分辨率而产生误导性误差。

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