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Novel molecular targets in pain control

机译：控制疼痛的新型分子靶标

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The complexity of pain processing in clinical pain conditions and in animal models has revealed many time-related changes and an abundance of molecular drug targets. There continues to be insecurity, however, about new target validation in clinical pain and thus most analgesia development is of high risk for evolving new pain therapies. The present review highlights a number of molecular targets being pursued for pain control.Many pain targets are critically dependent on the pain model/ lesion type. Neural and glial plasticity, ranging from changes in molecular expression and receptor phosphorylation to profound morphological reorganization, has been described under these conditions. Pain modulation has been shown to involve all major families of regulatory proteins such as the G-protein coupled receptors, ion channels, regulatory enzymes, neurotrophins, and kinases, offering an abundance of targets and therapeutic opportunities for symptomatic pain relief.Many molecular targets have been highlighted with some being the focus of current analgesia research. Some of these (e.g. vanilloid receptor 1, cannabinoid receptor 1, sodium channel NaV 1.8) have been evaluated in animal studies and in preliminary clinical studies, but others are highly novel and riskier analgesia pain targets (e.g. metabotropic glutamate receptors, sensory neurone specific receptors, kinase inhibitors).
机译：临床疼痛状况和动物模型中疼痛处理的复杂性揭示了许多与时间相关的变化以及大量的分子药物靶标。然而，关于临床疼痛中新靶标验证的继续存在不安全感，因此大多数镇痛药开发发展新的疼痛疗法的风险很高。本综述重点介绍了许多用于控制疼痛的分子靶标。许多疼痛靶标严重依赖于疼痛模型/病变类型。在这些条件下，已经描述了神经和神经胶质的可塑性，范围从分子表达的变化和受体磷酸化到深刻的形态重组。疼痛调节已被证实涉及所有主要的调节蛋白家族，例如G蛋白偶联受体，离子通道，调节酶，神经营养蛋白和激酶，为缓解症状性疼痛提供了丰富的靶点和治疗机会。强调了一些是当前镇痛研究的重点。其中一些（例如香草类受体1，大麻素受体1，钠通道NaV 1.8）已在动物研究和初步临床研究中进行了评估，但其他一些则是新型且风险更高的镇痛镇痛目标（例如代谢型谷氨酸受体，感觉神经元特异性受体）。 ，激酶抑制剂）。

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