Photoinduced anticancer effect evaluation of ruthenium(II) polypyridyl complexes toward human lung cancer A549 cells

He Miao; Du Fan; Zhang Wen-Yao; Yi Qiao-Yan; Wang Yang-Jie; Yin Hui; Bai Lan; Gu Yi-Ying; Liu Yun-Jun

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Photoinduced anticancer effect evaluation of ruthenium(II) polypyridyl complexes toward human lung cancer A549 cells

机译：钌（II）钌（II）聚吡啶复合物对人肺癌A549细胞的光致抗癌效应评价

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In recent years, ruthenium complexes have attracted extensive attention as new anticancer drugs. In this paper, three new ruthenium complexes [Ru(dmb)(2)(HMNPIP)](PF6)(2) (1), [Ru(bpy)(2)(HMNPIP)](PF6)(2) (2) and [Ru(phen)(2)(HMNPIP)](PF6)(2) (3) (HMNPIP = 2-hydroxy-3-methoxy-5-nitrophenylimidazo[4,5-f] [1,10]phenanthroline) were synthesized and characterized by elemental analysis, ESI-MS, H-1 NMR and C-13 NMR. The MIT assays showed that the complexes have no cytotoxic activity in vitro. However, upon irradiation with white light, the complexes display high anticancer activity toward A549 cells. The cell cycle distribution and apoptosis of A549 cells induced by the complexes were investigated by flow cytometry. The intracellular ROS and calcium ion levels were studied. The change of mitochondria! membrane potential, cell invasion were also investigated. The expression of caspase 3, p53 and Bcl-2 family proteins was explored by western blot. The complexes induce apoptosis in A549 cells through intrinsic pathway. (C) 2019 The Author(s). Published by Elsevier Ltd.

机译：近年来，钌综合体吸引了广泛的关注，作为新的抗癌药物。本文中，三种新的钌配合物[Ru（DMB）（2）（2）（HMNPIP）]（PF6）（2）（1），[Ru（BPY）（2）（HMNPIP）]（PF6）（2）（2）（2 ）和[Ru（phO）（2）（hmnpip）]（pf6）（2）（3）（hmnpip = 2-羟基-3-甲氧基-5-硝基苯基咪唑[4,5-f] [1,10]菲咯啉通过元素分析，ESI-MS，H-1 NMR和C-13 NMR合成并表征。麻省理工学院的测定表明，复合物在体外没有细胞毒性活性。然而，在用白光照射时，复合物向A549细胞显示高抗癌活性。通过流式细胞术研究了复合物诱导的A549细胞的细胞周期分布和凋亡。研究了细胞内ROS和钙离子水平。线粒体的变化！膜势也调查了细胞侵袭。通过蛋白质印迹探讨了Caspase 3，P53和Bcl-2家族蛋白的表达。复合物通过内在途径诱导A549细胞凋亡。（c）2019年作者。 elsevier有限公司出版

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来源
《Polyhedron: The International Journal for Inorganic and Organometallic Chemistry》 |2019年第2019期|共14页
作者
He Miao; Du Fan; Zhang Wen-Yao; Yi Qiao-Yan; Wang Yang-Jie; Yin Hui; Bai Lan; Gu Yi-Ying; Liu Yun-Jun;
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作者单位

Guangdong Pharmaceut Univ Sch Pharm Guangzhou 510006 Guangdong Peoples R China;

Guangdong Pharmaceut Univ Sch Pharm Guangzhou 510006 Guangdong Peoples R China;

Guangdong Pharmaceut Univ Sch Pharm Guangzhou 510006 Guangdong Peoples R China;

Guangdong Pharmaceut Univ Sch Pharm Guangzhou 510006 Guangdong Peoples R China;

Guangdong Pharmaceut Univ Sch Pharm Guangzhou 510006 Guangdong Peoples R China;

Guangdong Pharmaceut Univ Sch Pharm Guangzhou 510006 Guangdong Peoples R China;

Guangdong Pharmaceut Univ Sch Pharm Guangzhou 510006 Guangdong Peoples R China;

Guangdong Pharmaceut Univ Sch Pharm Guangzhou 510006 Guangdong Peoples R China;

Guangdong Engn Res Ctr Lead Cpds &

Drug Discovery Guangzhou 510006 Guangdong Peoples R China;

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正文语种 eng
中图分类无机化学;
关键词
Ruthenium(II) complexes; Cytotoxicity in vitro; Apoptosis; Cell invasion; Western blot;

机译：钌（II）复合物;细胞毒性在体外;细胞凋亡;细胞侵袭;蛋白质印迹;

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专利

1. Photoinduced anticancer effect evaluation of ruthenium(II) polypyridyl complexes toward human lung cancer A549 cells [J] . He Miao, Du Fan, Zhang Wen-Yao, Polyhedron: The International Journal for Inorganic and Organometallic Chemistry . 2019,第期

机译：钌（II）钌（II）聚吡啶复合物对人肺癌A549细胞的光致抗癌效应评价
2. The studies on bioactivity in vitro of ruthenium(II) polypyridyl complexes towards human lung carcinoma A549 cells [J] . Han Bing-Jie, Jiang Guang-Bin, Wang Ji, RSC Advances . 2014,第77期

机译：钌（Ⅱ）多吡啶配合物对人肺癌A549细胞的体外生物活性研究
3. Investigation of inducing apoptosis in human lung cancer A549 cells and related mechanism of a ruthenium(II) polypyridyl complex [J] . Chen Jin-can, Li Guo-dong, Peng Fa, Inorganic Chemistry Communications . 2016,第Null期

机译：诱导人肺癌A549细胞凋亡的研究及钌（II）多吡啶基配合物的相关机制
4. The Proliferative Inhibition and Apoptotic Mechanism of Saikosaponin D in Human Non-Small Cell Lung Cancer A549 Cells [C] . Jiang Dong, Yang Ru-song, Zheng Shi-ying, Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009 . 2009

机译：皂苷D在人非小细胞肺癌A549细胞中的增殖抑制及其凋亡机制
5. Ruthenium(II) polypyridyl complexes as potential anticancer drugs: Synthesis, characterization, cell permeability and locallization. [D] . Chen, Yanling. 2013

机译：钌（II）聚吡啶基复合物作为潜在的抗癌药：合成，表征，细胞通透性和定位性。
6. Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes [O] . R Carter, A Westhorpe, MJ Romero, -1

机译：钌（II）芳烃抗癌复合物对人大肠癌细胞的放射增敏作用
7. Inside Cover: Aquation Is a Crucial Activation Step for Anticancer Action of Ruthenium(II) Polypyridyl Complexes to Trigger Cancer Cell Apoptosis (Chem. Asian J. 2/2016) [O] . Meng Li, Lanhai Lai, Zhennan Zhao, 2016

机译：内部封面：施用是钌（II）聚吡啶复合物触发癌细胞凋亡的抗癌作用的关键活化步骤（化学。亚洲J.2 / 2016）

Photoinduced anticancer effect evaluation of ruthenium(II) polypyridyl complexes toward human lung cancer A549 cells

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