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首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >Utilizing molecular resonance-localized surface plasmon resonance coupling for copper ion detection in plasma
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Utilizing molecular resonance-localized surface plasmon resonance coupling for copper ion detection in plasma

机译：利用用于铜离子检测的分子共振局部表面等离子体谐振耦合等离子体中的铜离子检测

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摘要

The rapid, point-of-care detection of copper in plasma can greatly aid in a large number of diseases where copper has been implicated to be an important factor, such as cancer, Alzheimer’s and Diabetes mellitus. Localized surface plasmon resonance (LSPR) technologies show promise in the inexpensive detection of copper, whereas previous platforms are plagued with selectivity and sensitivity issues. Herein, we have created a sensitive and selective on-chip copper sensor which can produce a colorimetric reading in 60 minutes. The selectivity of the assay is based on ‘Click’ chemistry and is shown to have little interference with other metal ions present in plasma. The sensitivity of the assay is generated from the coupling of the molecular resonance of a dye and the LSPR of the gold nanoparticles. The assay is capable of measuring copper concentrations in human plasma as low as 4 μM and the linear range of sensitivity, 4 to 20 μM, is in the physiologically relevant range. This robust, colorimetric assay should prove useful in a point-of-care setting.
机译：血浆中铜的快速，护理点检测可以大大辅助铜的大量疾病，其中致力于癌症，阿尔茨海默氏症和糖尿病等重要因素。局部表面等离子体谐振（LSPR）技术在廉价检测中显示了承诺，而以前的平台困扰着选择性和灵敏度问题。在此，我们创建了一种敏感和选择性的片上铜传感器，其可以在60分钟内产生比色读数。测定的选择性基于“点击”化学，并显示出与等离子体中存在的其他金属离子的干扰几乎没有干扰。从染料的分子共振和金纳米颗粒的LSPR的偶联产生测定的敏感性。该测定能够测量人血浆中的铜浓度，低至4μm，敏感性的线性范围4至20μm在生理学上相关的范围内。这种稳健的比色测定应在护理点设置中证明。

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