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Quantitation of multiple sclerosis lesion volumes on magnetic resonance imaging

机译:磁共振成像定量多发性硬化病灶

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摘要

Multiple sclerosis is the most common demyelinating disease. Currently a number of clinical trials are underway for treating this disease. MRI-defined lesion burden is considered to be an useful marker for evaluating the efficacy of treatment. Quantitation of lesion burden in a clinical trial involving a large number of images requires a technique with minimal manual intervention. In this brief review we describe segmentation techniques, that are used in our laboratory, for automatic quantitation of lesion burden . A brief review of the novel pulse sequences for generating images with superior lesion-to-tissue contrast required for automatic lesion quantitation is also presented.
机译:多发性硬化症是最常见的脱髓鞘疾病。目前,正在进行治疗该疾病的许多临床试验。 MRI定义的病变负荷被认为是评估治疗效果的有用标志。在涉及大量图像的临床试验中,对病变负荷的定量需要一种最少人工干预的技术。在这篇简短的综述中,我们描述了在我们的实验室中用于自动定量病变负荷的分割技术。还简要概述了新颖的脉冲序列,用于生成具有自动病变定量所需的优良的病变组织对比度的图像。

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