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Treatment of Helicobacter pylori

机译：幽门螺杆菌的治疗

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摘要

Helicobacter pylori causes several gastroduodenal diseases. Various antibiotic regimens are available that eradicate H. pylori in 80 to 90% of patients, but no regimen cures all patients. Dual therapy is now obsolete. Triple therapy with two antibiotics and either a proton pump inhibitor or bismuth is the regimens of choice. Metronidazole and clarithromycin are the two key antibiotics. Antibiotic resistance against these two drugs is becoming more problematic and should be taken into consideration when choosing a regimen. Antibiotic resistance is usually induced after failure. Quadruple therapy has been used as a salvage regimen in failed cases but it is also the most complicated regimen. Several new agents are being studied including a single capsule that contains bismuth, metronidazole, and tetracycline.
机译：幽门螺杆菌引起几种胃十二指肠疾病。可以使用多种抗生素方案在80％至90％的患者中根除幽门螺杆菌，但没有一种方案可以治愈所有患者。双重疗法现已淘汰。选择使用两种抗生素和质子泵抑制剂或铋的三联疗法。甲硝唑和克拉霉素是两种关键的抗生素。对这两种药物的抗生素耐药性正变得越来越成问题，在选择治疗方案时应予以考虑。失败后通常会引起抗生素耐药性。在失败的病例中，四联疗法已被用作挽救方案，但它也是最复杂的方案。正在研究几种新药，包括含有铋，甲硝唑和四环素的单个胶囊。

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