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首页> 外文期刊>Current opinion in gastroenterology >Probiotics: progress toward novel therapies for intestinal diseases.
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Probiotics: progress toward novel therapies for intestinal diseases.

机译：益生菌：朝着治疗肠道疾病的新疗法迈进。

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摘要

PURPOSE OF REVIEW: As the beneficial effects of probiotics on health and disease prevention and treatment have been well recognized, the demand for probiotics in clinical applications and as functional foods has significantly increased in spite of limited understanding of the mechanisms. This review focuses on the most recent advances in probiotic research from genetics to biological consequences regulated by probiotics and probiotic-derived factors. RECENT FINDINGS: Genomic and proteomic studies reveal genes and proteins involved in probiotic adaptation in the host and while exerting their beneficial effects. Recent studies in cell culture and in animal models emphasize probiotic functions in intestinal development, nutrition, host microbial balance, cytoprotection, barrier function, innate immunity, and inflammation. Most importantly, several novel and known probiotic-derived factors have been characterized, which regulate host-signaling pathways and mediate probiotic function. SUMMARY: Progress in understanding probiotic mechanisms of action will increase our basic understanding of biological crosstalk and provide the rationale to support the development of new hypothesis-driven studies to define the clinical efficacy of probiotics for intestinal disorders.
机译：审查目的：由于益生菌对健康和疾病预防与治疗的有益作用已得到公认，尽管对作用机理的了解有限，但对临床应用和功能性食品中益生菌的需求已大大增加。这篇综述着重于益生菌研究的最新进展，从遗传学到益生菌和益生菌衍生因子调控的生物学后果。最近的发现：基因组和蛋白质组学研究揭示了与宿主中益生菌适应有关的基因和蛋白质，同时发挥了有益作用。细胞培养和动物模型方面的最新研究强调了益生菌在肠道发育，营养，宿主微生物平衡，细胞保护，屏障功能，先天免疫和炎症中的功能。最重要的是，已表征了几种新颖且已知的益生菌衍生因子，它们调节宿主信号通路并介导益生菌功能。摘要：了解益生菌作用机理的进展将增加我们对生物学串扰的基本理解，并提供理论依据以支持新的假设驱动研究的发展，以定义益生菌对肠道疾病的临床疗效。

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