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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Reduced Structural Connectivity Between Left Auditory Thalamus and the Motion-Sensitive Planum Temporale in Developmental Dyslexia
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Reduced Structural Connectivity Between Left Auditory Thalamus and the Motion-Sensitive Planum Temporale in Developmental Dyslexia

机译：减少左侧听觉丘脑与发育综合征中的运动敏感Planum临时之间的结构性连通性

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摘要

Developmental dyslexia is characterized by the inability to acquire typical reading and writing skills. Dyslexia has been frequently linked to cerebral cortex alterations; however, recent evidence also points toward sensory thalamus dysfunctions: dyslexics showed reduced responses in the left auditory thalamus (medial geniculate body, MGB) during speech processing in contrast to neurotypical readers. In addition, in the visual modality, dyslexics have reduced structural connectivity between the left visual thalamus (lateral geniculate nucleus, LGN) and V5/MT, a cerebral cortex region involved in visual movement processing. Higher LGN-V5/MT connectivity in dyslexics was associated with the faster rapid naming of letters and numbers (RANIn), a measure that is highly correlated with reading proficiency. Here, we tested two hypotheses that were directly derived from these previous findings. First, we tested the hypothesis that dyslexics have reduced structural connectivity between the left MGB and the auditory-motion-sensitive part of the left planum temporale (mPT). Second, we hypothesized that the amount of left mPT MGB connectivity correlates with dyslexics RANIn scores. Using diffusion tensor imaging-based probabilistic tracking, we show that male adults with developmental dyslexia have reduced structural connectivity between the left MGB and the left mPT, confirming the first hypothesis. Stronger left mPT MGB connectivity was not associated with faster RANIn scores in dyslexics, but was in neurotypical readers. Our findings provide the first evidence that reduced cortico-thalamic connectivity in the auditory modality is a feature of developmental dyslexia and it may also affect reading-related cognitive abilities in neurotypical readers.
机译：发展障碍的特点是无法获得典型的阅读和写作技巧。综合症经常与脑皮质改变有关;然而，最近的证据还指向感官丘脑功能障碍：缺点在与神经型读者相比的语音处理期间在左侧听觉丘脑（内侧核肉体，MGB）中表现出降低的反应。此外，在视觉形态，诵读困难减少了左视觉丘脑（外侧膝状体，LGN）和V5 / MT，参与视觉运动的处理的大脑皮层区域之间的结构连接。缺点仪器中的较高LGN-V5 / MT连接与字母和数字的快速命名（RANIN）的快速命名相关联，这是一种与阅读熟练度高度相关的措施。在这里，我们测试了直接从这些前面发现的两个假设。首先，我们测试了疑难智的假设，即左侧MGB和左侧Planum休闲部分（MPT）之间的结构连接降低了结构连接。其次，我们假设左MPT MGB连接量与缺点朗宁分数相关。使用扩散张量成像的概率跟踪，我们表明，具有发育综合征的雄性成年人在左MGB和左侧MPT之间具有降低的结构连接，确认了第一个假设。更强大的左MPT MGB连接与缺点论中的令人难题的分数更快，但在神经典型读者中。我们的研究结果提供了第一种证据，即减少皮质 - 丘脑连接在听觉模型中是发育综合症的一种特征，也可能影响神经典型读者中的阅读相关认知能力。

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