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Mechanisms of action of zinc in acute diarrhea

机译：锌在急性腹泻中的作用机理

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Purpose of review For over a decade, the importance of zinc in the treatment of acute diarrhea has been recognized. More recently, the mechanisms of action of zinc are becoming clearer. This review is focused on the new evidence on the mechanisms of action of zinc in acute diarrhea. Recent findings The vast majority of data derive from in-vitro studies using intestinal cell lines or from animal model. The positive action by zinc in acute diarrhea derives from a regulation of intestinal fluid transport, mucosal integrity, immunity, gene expression, and oxidative stress. A complex homeostatic network is also able to regulate zinc status at cellular and extracellular level. Summary All these data support the use of zinc in the treatment of acute diarrhea, but further clinical studies are needed to explore the selective effects of zinc against specific pathogens responsible for diarrhea.
机译：审查目的十多年来，人们已经认识到锌在治疗急性腹泻中的重要性。最近，锌的作用机理变得更加清晰。这篇综述集中在锌在急性腹泻中作用机理的新证据。最新发现绝大多数数据来自使用肠道细胞系的体外研究或动物模型。锌在急性腹泻中的积极作用源自对肠液运输，粘膜完整性，免疫力，基因表达和氧化应激的调节。复杂的稳态网络还能够在细胞和细胞外水平调节锌的状态。总结所有这些数据都支持锌在急性腹泻中的应用，但是还需要进一步的临床研究来探讨锌对引起腹泻的特定病原体的选择性作用。

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