...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in gastroenterology >The colonic microflora and probiotic therapy in health and disease
【24h】

The colonic microflora and probiotic therapy in health and disease

机译：结肠菌群和益生菌在健康和疾病中的治疗

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose of review Host-microbe dialogue is involved not only in maintenance of mucosal homeostasis but also in the pathogenesis of several infectious, inflammatory, and neoplastic disorders of the gut. This has led to a resurgence of interest in the colonic microbiota in health and disease. Recent landmark findings are addressed here. Recent findings Reciprocal signalling between the immune, system and the microbiota plays a pivotal role in linking alterations in gut microbiota with risk of metabolic disease in the host, notably insulin resistance, obesity, and chronic low-grade inflammation. Loss of ancestral indigenous organisms consequent upon a modern lifestyle may contribute to an increased frequency of various metabolic and immuno-allergic diseases. The potential to address this underpins the science of pharmabiotics. Summary Advances in understanding host-microbe interactions within the gut can inform rational probiotic or pharmabiotic selection criteria. In addition, the gut microbiota may be a repository for drug discovery as well as a therapeutic target.
机译：综述的目的宿主与微生物的对话不仅涉及粘膜稳态的维持，而且还涉及几种肠道传染性，炎性和赘生性疾病的发病机理。这导致人们对健康和疾病中结肠菌群的兴趣重新兴起。此处介绍了近期的标志性发现。最新发现免疫系统和微生物群之间的相互信号在将肠道微生物群的改变与宿主代谢疾病的风险（尤其是胰岛素抵抗，肥胖症和慢性低度炎症）联系起来方面起着关键作用。现代生活方式导致祖先土著生物的流失可能导致各种新陈代谢和免疫过敏性疾病的发生率增加。解决这一问题的潜力巩固了药物生物科学。小结理解肠道内宿主-微生物相互作用的进展可以为合理的益生菌或药典选择标准提供参考。另外，肠道菌群可以是用于药物发现以及治疗靶标的储存库。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号