...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Surgery >Do proton pump inhibitors increase the incidence of nosocomial pneumonia and related infectious complications when compared with histamine-2 receptor antagonists in critically ill trauma patients?
【24h】

Do proton pump inhibitors increase the incidence of nosocomial pneumonia and related infectious complications when compared with histamine-2 receptor antagonists in critically ill trauma patients?

机译：与组胺2受体拮抗剂相比，质子泵抑制剂在重症创伤患者中是否会增加医院内肺炎和相关感染并发症的发生率？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Proton pump inhibitors (PPI) may increase the risk of nosocomial pneumonia caused by profound irreversible gastric acid suppression. The study purpose was to characterize differences in nosocomial pneumonia and related infections in trauma patients administered either histamine(2)-receptor antagonists (H2RA) or PPI. METHODS: Observational evaluation of consecutive critically ill adult trauma patients administered either omeprazole or famotidine during a 22-month period. Nosocomial infection was evaluated daily based on published CDC definitions. RESULTS: Eighty of 269 patients fulfilled study criteria. The PPI group (n = 40) exhibited increased baseline risk for infection, demonstrated by higher ISS (p = 0.020), more chest tube placements (p = 0.031), and increased chest trauma (p = 0.025). Overall number of patients infected per group included 33% and 40% of patients administered PPI and H2RA, respectively (p = 0.64). Despite baseline differences, the incidence of nosocomial infection was similar (p = 0.87), and extrapolation of pneumonia based on 1000 patient days revealed a ratio 51.7 vs 52.2 in the PPI vs H2RA groups, respectively, which was not significant (p = 0.99). CONCLUSIONS: Proton pump inhibitor administration does not increase risk of nosocomial pneumonia or other nosocomial infections compared with H2RA therapy in the critically ill trauma patient.
机译：背景：质子泵抑制剂（PPI）可能会增加由不可逆的强烈胃酸抑制引起的医院内肺炎的风险。该研究的目的是鉴定在使用组胺（2）-受体拮抗剂（H2RA）或PPI的创伤患者中医院内肺炎和相关感染的差异。方法：在22个月内连续服用奥美拉唑或法莫替丁的危重成人创伤患者的观察性评估。每天根据已发布的CDC定义评估医院感染。结果：269名患者中有80名符合研究标准。 PPI组（n = 40）表现出更高的感染基线风险，表现为较高的ISS（p = 0.020），更多的胸管放置（p = 0.031）和增加的胸外伤（p = 0.025）。每组感染的患者总数分别包括接受PPI和H2RA的患者的33％和40％（p = 0.64）。尽管存在基线差异，但医院感染的发生率相似（p = 0.87），根据1000个患者日的肺炎推断，PPI与H2RA组的比率分别为51.7 vs 52.2，但无统计学意义（p = 0.99）。 。结论：与H2RA治疗相比，质子泵抑制剂在重症创伤患者中的使用不会增加医院内肺炎或其他医院感染的风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号