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首页> 外文期刊>Current opinion in lipidology >Triglyceride containing lipid droplets and lipid droplet-associated proteins.
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Triglyceride containing lipid droplets and lipid droplet-associated proteins.

机译：含甘油三酸酯的脂质滴和脂质滴相关蛋白。

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PURPOSE OF REVIEW: Cytosolic lipid droplets are now recognized as dynamic organelles. This review summarizes our current understanding of the mechanisms involved in the formation of lipid droplets, the importance of lipid droplet-associated proteins and the link between lipid droplet accumulation and development of insulin resistance. RECENT FINDINGS: Lipid droplets are formed as primordial droplets and they increase in size by fusion. This fusion process requires the alpha-soluble N-ethylmaleimide-sensitive factor adaptor protein receptor SNAP23, which is also involved in the insulin-dependent translocation of a glucose transporter to the plasma membrane. Recent data suggest that SNAP23 is the link between increased lipid droplet accumulation and development of insulin resistance. Lipid droplets also form tight interactions with other organelles. Furthermore, additional lipid droplet-associated proteins have been identified and shown to play a role in droplet assembly and turnover, and in sorting and trafficking events. SUMMARY: Recent studies have identified a number of key proteins that are involved in the formation and turnover of lipid droplets, and SNAP23 has been identified as a link between accumulation of lipid droplets and development of insulin resistance. Further understanding of lipid droplet biology could indicate potential therapeutic targets to prevent accumulation of lipid droplets and associated complications.
机译：审查的目的：囊性脂质滴现在被认为是动态细胞器。这篇综述总结了我们目前对脂滴形成机制，脂滴相关蛋白的重要性以及脂滴积累与胰岛素抵抗发展之间的联系的了解。最近发现：脂质液滴形成为原始液滴，它们通过融合而增大尺寸。该融合过程需要α-可溶性N-乙基马来酰亚胺敏感因子衔接子蛋白受体SNAP23，该受体也参与葡萄糖转运蛋白向质膜的胰岛素依赖性转运。最近的数据表明SNAP23是增加的脂质滴积累和胰岛素抵抗的发展之间的联系。脂质液滴还与其他细胞器形成紧密的相互作用。此外，已经鉴定了另外的脂质液滴相关蛋白，并显示它们在液滴装配和周转以及分类和运输事件中起作用。简介：最近的研究已经确定了许多与脂质小滴的形成和转换有关的关键蛋白，SNAP23已被确定为脂质小滴的积累与胰岛素抵抗发展之间的联系。对脂质小滴生物学的进一步了解可能表明潜在的治疗靶点，可以防止脂质小滴的积累和相关并发症。

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