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首页> 外文期刊>Current opinion in lipidology >Apolipoprotein E receptors in the nervous system.
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Apolipoprotein E receptors in the nervous system.

机译：神经系统中的载脂蛋白E受体。

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摘要

PURPOSE OF REVIEW: Over the past few years, apolipoprotein E (ApoE) receptors, also known as LDL receptor-related proteins, have distinguished themselves as functionally diverse signaling receptors with pivotal roles not only in the vascular system but also in the nervous system and during development. RECENT FINDINGS: The expanding roles of ApoE receptors for cellular signal transduction at the same time transcend and integrate their lipid transport roles into a larger biological and clinical context. ApoE receptors are essential for the development of the nervous system, the regulation of synaptic plasticity, neuroprotection and the innervation of the muscle. They also regulate the metabolism of the amyloid precursor protein on multiple levels, implicating them in the pathogenesis of Alzheimer's disease. SUMMARY: ApoE, a common ligand for all members of the evolutionarily ancient LDL receptor gene family, is the major genetic modifier of the age of onset of Alzheimer's disease. The underlying molecular mechanisms remain shrouded in mystery, but the numerous critical functions of ApoE receptors within and outside the nervous system that have recently emerged make it likely that these multifunctional signal modulators participate in Alzheimer's disease pathogenesis. This review attempts to summarize the most recent and relevant findings in this area.
机译：审查的目的：在过去的几年中，载脂蛋白E（ApoE）受体（也称为LDL受体相关蛋白）已经成为功能多样的信号受体，不仅在血管系统中而且在神经系统和神经系统中起着关键作用。在开发过程中。最近的发现：ApoE受体在细胞信号转导中的作用日益扩大，同时又超越了它们的脂质转运作用，并将其整合到更大的生物学和临床环境中。 ApoE受体对于神经系统的发育，突触可塑性的调节，神经保护和肌肉的神经活动至关重要。它们还以多个水平调节淀粉样前体蛋白的代谢，使它们参与阿尔茨海默氏病的发病机理。摘要：ApoE是进化上古老的LDL受体基因家族所有成员的通用配体，是阿尔茨海默氏病发病年龄的主要遗传修饰因子。潜在的分子机制仍处于谜团之中，但是最近出现的神经系统内外的ApoE受体的许多关键功能使这些多功能信号调节剂可能参与了阿尔茨海默氏病的发病机理。这篇综述试图总结该领域的最新和相关发现。

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