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首页> 外文期刊>Current opinion in lipidology >Hypoalphalipoproteinemia in populations of Native American ancestry: an opportunity to assess the interaction of genes and the environment.
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Hypoalphalipoproteinemia in populations of Native American ancestry: an opportunity to assess the interaction of genes and the environment.

机译：美国原住民血统中的低α脂蛋白血症：评估基因与环境相互作用的机会。

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摘要

PURPOSE OF THIS REVIEW: Our aim is to review the environmental and genetic factors associated with hypoalphalipoproteinemia in populations of Native American ancestry. We examine the strength of the association and outline the population-specific genetic factors that lead to a higher susceptibilty for this condition. RECENT FINDINGS: Low HDL is the most common lipid abnormality in populations of Native American ancestry. Population-based surveys carried out in Latin America and in Mexican Americans shows that 40-60% of adults have hypoalphalipoproteinemia. The contribution of this trait to the metabolic syndrome is greater in individuals with Native American ancestry than in other ethnic groups. Several environmental factors have contributed to this phenomenon (i.e. high dietary content of carbohydrates and fat due to cultural factors and a growing incidence of obesity). In addition, results from recent genetic studies show that certain hypoalphalipoproteinemia susceptibility alleles are ethnic specific for Native Americans. The variant R230C of the ATP-binding cassette transporter subfamily A member 1 gene (ABC-A1) is common among mestizos (10.9% in Mexican mestizos) and its presence has a significant negative effect on HDL cholesterol levels (-4.2%). An additional noteworthy finding is that the R230C variant appears to be specific for the Amerindian populations. Its allele frequency is 0.28 in Mayans, 0.214 in Purepechas, 0.203 in Yaquis and 0.179 among Teenek. In contrast, the C230 allele has not been found in African, European, Chinese or South Asian populations. SUMMARY: The assessment of the genetic and environmental determinants of hypoalphalipoproteinemia in populations of Native American origin provides an opportunity to assess the population-specific interactions between genes and the environment
机译：这次审查的目的：我们的目的是审查与美国原住民血统的低α脂蛋白血症相关的环境和遗传因素。我们检查了这种关联的强度，并概述了导致这种情况敏感性更高的特定人群遗传因素。最近的发现：低HDL是美国原住民血统中最常见的脂质异常。在拉丁美洲和墨西哥裔美国人中进行的基于人口的调查显示，有40-60％的成年人患有低脂蛋白血症。具有美国原住民血统的人比其他种族群体对新陈代谢综合症的贡献更大。造成这种现象的原因有多种（例如，由于文化因素和肥胖发生率的增加，碳水化合物和脂肪的高饮食含量）。此外，最近的遗传研究结果表明，某些低脂蛋白血症易感性等位基因是美洲原住民的种族特有基因。 ATP结合盒转运蛋白亚家族A成员1基因（ABC-A1）的变体R230C在混血儿中很常见（墨西哥混血儿中为10.9％），并且其存在对HDL胆固醇水平具有显着的负面影响（-4.2％）。另一个值得注意的发现是R230C变体似乎是针对美洲印第安人种群的。它的等位基因频率在玛雅人中为0.28，在Purepechas中为0.214，在Yaquis中为0.203，在Teenek中为0.179。相反，在非洲，欧洲，中国或南亚人群中未发现C230等位基因。摘要：对美国原住民群体中低脂蛋白血症的遗传和环境决定因素的评估为评估基因与环境之间特定人群的相互作用提供了机会

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