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Citrus flavonoids and lipid metabolism

机译：柑橘类黄酮与脂质代谢

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PURPOSE OF REVIEW: Citrus flavonoids are polyphenolic compounds with powerful biological properties. This review aims to summarize recent advances towards understanding the ability of citrus flavonoids to regulate lipid metabolism and other metabolic parameters relevant to the metabolic syndrome, type 2 diabetes and cardiovascular disease. RECENT FINDINGS: Citrus flavonoids, including naringenin, hesperidin, nobiletin and tangeretin, have emerged as promising therapeutic agents for the treatment of metabolic dysregulation. Epidemiological studies report that intake of citrus flavonoid-containing foods attenuates cardiovascular diseases. Experimental and a limited number of clinical studies reveal lipid-lowering, insulin-sensitizing, antihypertensive and anti-inflammatory properties. In animal models, citrus flavonoid supplements prevent hepatic steatosis, dyslipidemia and insulin sensitivity primarily through inhibition of hepatic fatty acid synthesis and increased fatty acid oxidation. Citrus flavonoids blunt the inflammatory response in metabolically important tissues including liver, adipose tissue, kidney and the aorta. The mechanisms underlying flavonoid-induced metabolic regulation have not been completely established. In mouse models, citrus flavonoids show marked suppression of atherogenesis through improved metabolic parameters and also through direct impact on the vessel wall. SUMMARY: These recent studies suggest an important role of citrus flavonoids in the treatment of dyslipidemia, insulin resistance, hepatic steatosis, obesity and atherosclerosis. The favorable outcomes are achieved through multiple mechanisms. Human studies focussed on dose, bioavailability, efficacy and safety are required to propel the use of these promising therapeutic agents into the clinical arena. ? 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
机译：审查目的：柑橘类黄酮是具有强大生物学特性的多酚类化合物。这篇综述旨在总结了解柑桔类黄酮调节脂质代谢和与代谢综合征，2型糖尿病和心血管疾病相关的其他代谢参数的能力的最新进展。最近的发现：柑桔类黄酮，包括柚皮苷，橙皮苷，诺比列汀和坦格列汀，已成为治疗代谢异常的有前途的治疗剂。流行病学研究报告称，摄入含有柑橘类黄酮的食物可减轻心血管疾病。实验和有限的临床研究表明，它们具有降脂，胰岛素增敏，降压和抗炎的特性。在动物模型中，柑橘类黄酮补充剂主要通过抑制肝脂肪酸合成和增加脂肪酸氧化来预防肝脂肪变性，血脂异常和胰岛素敏感性。柑橘类黄酮在包括肝脏，脂肪组织，肾脏和主动脉在内的代谢重要组织中抑制炎症反应。类黄酮诱导的代谢调节的机制尚未完全建立。在小鼠模型中，柑桔类黄酮通过改善代谢参数以及直接影响血管壁显示出明显的动脉粥样硬化抑制作用。摘要：这些最新研究表明，柑桔类黄酮在血脂异常，胰岛素抵抗，肝脂肪变性，肥胖症和动脉粥样硬化的治疗中具有重要作用。有利的结果是通过多种机制实现的。人类研究集中在剂量，生物利用度，功效和安全性上，以推动将这些有前途的治疗剂推广到临床领域。 ？ 2013威科集团健康|利平科特·威廉姆斯和威尔金斯。

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