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首页> 外文期刊>Current opinion in lipidology >Peroxisome proliferator-activated receptor ??: A multifaceted metabolic player
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Peroxisome proliferator-activated receptor ??: A multifaceted metabolic player

机译：过氧化物酶体增殖物激活受体??：多方面的代谢参与者

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PURPOSE OF REVIEW: Therapeutic strategies to alleviate the growing epidemic of insulin-resistant syndromes (obesity and type 2 diabetes) as well as the conferred cardiovascular disease risk remain sparse. The peroxisome proliferator-activated receptor ?? (PPAR??) has emerged as a versatile regulator of lipid homeostasis and inflammatory signaling, making it an attractive therapeutic target for the treatment and prevention of type 2 diabetes and atherosclerosis. RECENT FINDINGS: PPAR?? activation regulates lipid homeostasis and inflammatory signaling in a variety of cell types, conferring protection from metabolic disease and atherosclerosis. Specifically, PPAR?? activation in the liver stimulates glucose utilization and inhibits gluconeogenesis, which improves insulin resistance and hyperglycemia. In macrophages, PPAR??-specific activation with synthetic agonists inhibits VLDL-induced triglyceride accumulation and inflammation. In mice, PPAR?? agonists halt the progression of atherosclerosis and stabilize existing lesions by promoting an anti-inflammatory milieu within the diseased macrovasculature. In humans, PPAR?? activation improves insulin sensitivity and reduces atherogenic dyslipidemia via a mechanism complementary to statin monotherapy. SUMMARY: Recent advances in the understanding of PPAR?? reveal that activation of this receptor represents a multifaceted therapeutic strategy for the prevention and treatment of insulin-resistant syndromes and atherosclerosis. ? 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
机译：审查目的：缓解胰岛素抵抗综合征（肥胖症和2型糖尿病）流行病以及赋予心血管疾病风险的治疗策略仍然很少。过氧化物酶体增殖物激活受体（PPARα）已成为脂质稳态和炎症信号的通用调节剂，使其成为治疗和预防2型糖尿病和动脉粥样硬化的有吸引力的治疗靶标。最近发现：PPAR？激活调节多种细胞类型中的脂质稳态和炎性信号传导，从而保护其免受代谢性疾病和动脉粥样硬化的侵害。具体来说，PPAR？肝脏中的活化刺激葡萄糖利用并抑制糖异生，从而改善胰岛素抵抗和高血糖症。在巨噬细胞中，用合成激动剂进行的PPARα-特异性活化抑制了VLDL诱导的甘油三酸酯积累和炎症。在小鼠中，PPAR ？？？激动剂通过促进患病的大血管内的抗炎环境来阻止动脉粥样硬化的进展并稳定现有的病变。在人类中，PPAR？激活通过补充他汀类药物单一疗法的机制提高胰岛素敏感性并减少动脉粥样硬化血脂异常。摘要：了解PPAR的最新进展？揭示该受体的激活代表了预防和治疗胰岛素抵抗综合征和动脉粥样硬化的多方面治疗策略。 ？ 2013威科集团健康|利平科特·威廉姆斯和威尔金斯。

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