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首页> 外文期刊>Current opinion in lipidology >Lowering dietary n-6 polyunsaturated fatty acids: interaction with brain arachidonic and docosahexaenoic acids
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Lowering dietary n-6 polyunsaturated fatty acids: interaction with brain arachidonic and docosahexaenoic acids

机译：降低饮食中的n-6多不饱和脂肪酸：与大脑花生四烯酸和二十二碳六烯酸的相互作用

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Purpose of reviewArachidonic (ARA) and docosahexaenoic (DHA) acids are the most abundant polyunsaturated fatty acids (PUFA) in the brain, where they have many biological effects, including on inflammation, cell-signaling, appetite regulation, and blood flow. The Western diet contains a high ratio of n-6: n-3 PUFA. Although interest in lowering this ratio has largely focused on increasing intake of n-3 PUFA, few studies have examined lowering dietary n-6 PUFA. This review will evaluate the effect of lowering dietary n-6 PUFA on levels and metabolism of ARA and DHA in animal models and in humans, with a primary focus on the brain.Recent findingsIn animal models, lowering dietary ARA or linoleic acid generally lowers levels of brain ARA and raises DHA. Lowering dietary n-6 PUFA can also modulate the levels of ARA and DHA metabolizing enzymes, as well as their associated bioactive mediators. Human studies examining changes in plasma fatty acid composition following n-6 PUFA lowering demonstrate no changes in levels of ARA and DHA, though there is evidence of alterations in their respective bioactive mediators.SummaryLowering dietary n-6 PUFA, in animal models, can alter the levels and metabolism of ARA and DHA in the brain, but it remains to be determined whether these changes are clinically meaningful.
机译：审查目的花生四烯酸（ARA）和二十二碳六烯酸（DHA）是大脑中含量最丰富的多不饱和脂肪酸（PUFA），在大脑中它们具有许多生物学作用，包括对炎症，细胞信号传导，食欲调节和血流的影响。西方饮食中n-6：n-3 PUFA的比例很高。尽管降低此比例的兴趣主要集中在增加n-3 PUFA的摄入量，但很少有研究研究降低饮食中的n-6 PUFA。这篇综述将评估降低饮食中n-6 PUFA对动物模型和人类中ARA和DHA的水平和代谢的影响，主要关注大脑。最近的发现在动物模型中，降低饮食ARA或亚油酸通常会降低水平ARA并提高DHA。降低饮食中的n-6 PUFA还可调节ARA和DHA代谢酶及其相关生物活性介质的水平。人类研究检查了n-6 PUFA降低后血浆脂肪酸组成的变化，尽管有证据表明它们各自的生物活性介质发生了变化，但ARA和DHA的水平没有变化。脑中ARA和DHA的水平和代谢，但是这些变化是否具有临床意义尚待确定。

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