Hepatic lipase and HDL metabolism.

Thuren T

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Hepatic lipase and HDL metabolism.

机译：肝脂肪酶和HDL代谢。

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Hepatic lipase is a lipolytic enzyme that has been suggested to have a role in HDL metabolism. Evidence suggests that HDL-cholesterol level is at least partly regulated by hepatic lipase level. Recent studies have shown that hepatic lipase not only hydrolyzes triglyceride and phospholipid in HDL, but also stimulates HDL cholesterol ester uptake by hepatocytes. Therefore, hepatic lipase, together with lipid transfer proteins, determines both HDL-cholesterol level and its function in reverse cholesterol transport. These conclusions are based on observations from in-vitro model substrate studies, cell culture studies, transgenic animal studies, and clinical studies. At present time, it is not known whether hepatic lipase action increases or decreases risk of developing atherosclerosis.

机译：肝脂肪酶是一种脂解酶，已被证明在HDL代谢中起作用。有证据表明，HDL-胆固醇水平至少部分受肝脂肪酶水平调节。最近的研究表明，肝脂肪酶不仅可以水解HDL中的甘油三酸酯和磷脂，还可以刺激肝细胞摄取HDL胆固醇酯。因此，肝脂肪酶与脂质转移蛋白一起决定了HDL-胆固醇水平及其在逆向胆固醇转运中的功能。这些结论基于体外模型底物研究，细胞培养研究，转基因动物研究和临床研究的观察结果。目前，尚不知道肝脂肪酶的作用是否会增加或降低发生动脉粥样硬化的风险。

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《Current opinion in lipidology》 |2000年第3期|共7页
作者
Thuren T;
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正文语种 eng
中图分类生物化学;
关键词
Lipase; Lipoproteins; HDL; Liver; 脂酶; 脂蛋白类; HDL; 肝;

机译：Lipase;Lipoproteins;HDL;Liver;脂酶;脂蛋白类;HDL;肝;

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1. Hepatic lipase and HDL metabolism. [J] . Thuren T Current opinion in lipidology . 2000,第3期

机译：肝脂肪酶和HDL代谢。
2. Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity. [J] . Rashid S, Watanabe T, Sakaue T, Clinical Biochemistry . 2003,第6期

机译：在胰岛素抵抗，高甘油三酸酯血症状态下HDL降低的机制：HDL甘油三酸酯富集和肝脂肪酶活性升高的综合作用。
3. Promoter polymorphisms of hepatic lipase gene influence HDL(2) but not HDL(3) in African American men: CARDIA study. [J] . Juo SH, Han Z, Smith JD, Journal of Lipid Research . 2001,第2期

机译：肝脂肪酶基因的启动子多态性影响非裔美国人中的HDL（2）但不影响HDL（3）：CARDIA研究。
4. Apolipoprotein kinetics measured in human HDL by HR/AM-PRM unveils a novel picture of HDL metabolism. [C] . Lang Ho Lee, Allison B. Andraski, Brett Pieper, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：HR / AM-PRM在人HDL中测量的载脂蛋白动力学推出了一种新颖的HDL代谢图像。
5. HDL-apoE content regulates the cell surface displacement of hepatic lipase [D] . Young, Elizabeth 2009

机译：HDL-apoE含量调节肝脂肪酶的细胞表面位移
6. Elevated High-Density Lipoprotein (HDL) Levels due to Hepatic Lipase Mutations Do Not Reduce Cardiovascular Disease Risk: Another Strike against the HDL Dogma [O] . Sergio Fazio, MacRae F. Linton -1

机译：肝脂肪酶突变导致高密度脂蛋白（HDL）水平升高不会降低心血管疾病的风险：针对HDL教条的另一项打击
7. Common Variants in the Promoter of the Hepatic Lipase Gene Are Associated With Lower Levels of Hepatic Lipase Activity, Buoyant LDL, and Higher HDL 2 Cholesterol [O] . Alberto Zambon, Samir S. Deeb, John E. Hokanson, 1998

机译：肝脂肪酶基因的启动子中的常见变体与较低水平的肝脂肪酶活性，浮标和更高的HDL 2胆固醇有关

Hepatic lipase and HDL metabolism.

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